Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: Farah Hasan
LAB HEAD: Patrick O'Donoghue
PROVIDER: PXD034180 | Pride | 2024-05-21
REPOSITORIES: Pride
Items per page: 1 - 5 of 12 |
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20230111 1871
By linking amino acids to their codon assignments, transfer RNAs (tRNAs) are essential for protein synthesis and translation fidelity. Some human tRNA variants cause amino acid mis-incorporation at a codon or set of codons. We recently found that a naturally occurring tRNA<sup>Ser</sup> variant decodes phenylalanine codons with serine and inhibits protein synthesis. Here, we hypothesized that human tRNA variants that misread glycine (Gly) codons with alanine (Ala) will also disrupt protein homeo ...[more]