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ChemBioID - An integrated chemical biology workflow for the analysis of inhibitor induced USP21 target proximity

ABSTRACT: Modulation of protein-protein interactions with small molecules represents an emerging area of interest in drug discovery, enabling new therapeutic paradigms unprecedented with other drug classes such as catalytic enzyme inhibitors. Immunomodulatory or PROTAC drugs are a prime example for proximity-induced pharmacology where in the case of multiple myeloma, degradation of oncogenic transcription factors is achieved via recruitment of an E3 ligase complex. This EUbOPEN project is a collaboration between ETHZ and UTOR which aims to identify target protein proximity induced by USP21 inhibitors.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Matthias Gstaiger

LAB HEAD: Matthias Gstaiger

PROVIDER: PXD041068 | Pride | 2023-04-25

REPOSITORIES: Pride

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			Action	DRS
	220727_EX1_sabkeller_Lib1.raw	Raw
	220727_EX1_sabkeller_Lib10.raw	Raw
	220727_EX1_sabkeller_Lib11.raw	Raw
	220727_EX1_sabkeller_Lib12.raw	Raw
	220727_EX1_sabkeller_Lib2.raw	Raw

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