Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ChemBioID - An integrated chemical biology workflow for the investigation of proximity-induced pharmacology of Lenalidomde

ABSTRACT: Modulation of protein-protein interactions with small molecules represents an emerging area of interest in drug discovery, enabling new therapeutic paradigms unprecedented with other drug classes such as catalytic enzyme inhibitors. Immunomodulatory or PROTAC drugs are a prime example for proximity-induced pharmacology where in the case of multiple myeloma, degradation of oncogenic transcription factors is achieved via recruitment of an E3 ligase complex. This project is part of the IMI EUbOPEN project.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Sabrina Keller

LAB HEAD: Matthias Gstaiger

PROVIDER: PXD041200 | Pride | 2023-04-26

REPOSITORIES: pride

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	20230216_203616_20230213_sabkeller_CRBN.kit	Other
	20230217_103323_20230217_sabkeller_CRBN_Report.setup.txt	Txt
	20230217_103323_20230217_sabkeller_CRBN_Report.xls	Xls
	230213_EX1_sabkeller_CRBN_DMSO1_2.raw	Raw
	230213_EX1_sabkeller_CRBN_DMSO2.raw	Raw

Items per page:

1 - 5 of 15

Similar Datasets

ChemBioID - An integrated chemical biology workflow for the investigation of proximity-induced pharmacology of CC-885

Project description:Modulation of protein-protein interactions with small molecules represents an emerging area of interest in drug discovery, enabling new therapeutic paradigms unprecedented with other drug classes such as catalytic enzyme inhibitors. Immunomodulatory or PROTAC drugs are a prime example for proximity-induced pharmacology where in the case of multiple myeloma, degradation of oncogenic transcription factors is achieved via recruitment of an E3 ligase complex. This project is part of the IMI EUbOPEN project.

2023-04-26 | PXD041128 | Pride

ChemBioID - An integrated chemical biology workflow for the investigation of proximity-induced pharmacology of Thalidomide

2023-04-26 | PXD041097 | Pride

ChemBioID - An integrated chemical biology workflow for the investigation of proximity-induced pharmacology of Iberdomide

2023-04-26 | PXD041081 | Pride

ChemBioID - An integrated chemical biology workflow for the analysis of pomalidomide induced target proximity

2023-04-25 | PXD041047 | Pride

ChemBioID - An integrated chemical biology workflow for the analysis of inhibitor induced USP21 target proximity

2023-04-25 | PXD041068 | Pride

Analyses of Rad2, Mediator and RNA Polymerase II in different yeast mutant context.

Project description:We performed ChIP-seq analyses of Rad2, Mediator (Med17 and Med5) and RNA Polymerase II in Kin28-ts16 mutant, Med17-Q444P and Med17-Q444P/M442L mutants and in an Rpb9 deleted strain.

2019-07-01 | E-MTAB-7081 | biostudies-arrayexpress

Circadian cycling of genome-wide histone methylation

Project description:Daily (circadian) clocks are essential for regulating and coordinating physiology in mammals. Modulation of local chromatin structure has been shown for only a small number of genes, principally thought to be directly modulated by Clock-mediated histone acetylation. Here we show that genome-wide changes of active and suppressive histone marks control global chromatin architecture over the day and night. Examination of mouse liver tissue at 4 time-points around the clock in "free-running", continuous conditions (constant darkness, temperature and food available ad libitum).

2013-01-08 | E-GEOD-23550 | biostudies-arrayexpress

Genome-wide analysis of p53 binding protein

Project description:Tumor suppressor p53 regulates various role in the cell including cell cycle arrest, DNA repair and apoptosis. Current research achieved to investigate p53 target genes in human osteosarcoma cell line-SaOS2 cell. Examination of p53 binding protein by transfecting flag-tagged wild type p53 into SaOS2 cells.

2014-04-01 | E-GEOD-51268 | biostudies-arrayexpress

Chromatin immunoprecipitation of human Hela cells grown under serum starved condtions to identify new targets genes for ETS-domain transcription factor Elk-1

Project description:Chromatin immunoprecipitation coupled with microarray analysis (ChIP-chip) was carried out to identify new target genes for ETS-domain transcription factor Elk-1. Experiment was done in Hela cells under serum starved conditions.

2009-08-11 | E-MEXP-1527 | biostudies-arrayexpress

Chromatin immunoprecipitation of human HeLa cells grown under serum starved conditions to identify new target genes for ETS-domain transcription factor Elk-1

2009-08-11 | E-MEXP-2084 | biostudies-arrayexpress