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ChemBioID - An integrated chemical biology workflow for the investigation of proximity-induced pharmacology of Lenalidomde

ABSTRACT: Modulation of protein-protein interactions with small molecules represents an emerging area of interest in drug discovery, enabling new therapeutic paradigms unprecedented with other drug classes such as catalytic enzyme inhibitors. Immunomodulatory or PROTAC drugs are a prime example for proximity-induced pharmacology where in the case of multiple myeloma, degradation of oncogenic transcription factors is achieved via recruitment of an E3 ligase complex. This project is part of the IMI EUbOPEN project.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Sabrina Keller

LAB HEAD: Matthias Gstaiger

PROVIDER: PXD041200 | Pride | 2023-04-26

REPOSITORIES: pride

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			Action	DRS
	20230216_203616_20230213_sabkeller_CRBN.kit	Other
	20230217_103323_20230217_sabkeller_CRBN_Report.setup.txt	Txt
	20230217_103323_20230217_sabkeller_CRBN_Report.xls	Xls
	230213_EX1_sabkeller_CRBN_DMSO1_2.raw	Raw
	230213_EX1_sabkeller_CRBN_DMSO2.raw	Raw

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