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ChemBioID - An integrated chemical biology workflow for the investigation of proximity-induced pharmacology of CC-885

ABSTRACT: Modulation of protein-protein interactions with small molecules represents an emerging area of interest in drug discovery, enabling new therapeutic paradigms unprecedented with other drug classes such as catalytic enzyme inhibitors. Immunomodulatory or PROTAC drugs are a prime example for proximity-induced pharmacology where in the case of multiple myeloma, degradation of oncogenic transcription factors is achieved via recruitment of an E3 ligase complex. This project is part of the IMI EUbOPEN project.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Sabrina Keller

LAB HEAD: Matthias Gstaiger

PROVIDER: PXD041128 | Pride | 2023-04-26

REPOSITORIES: pride

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			Action	DRS
	20230327_094739_20230327_sabkeller_CC_Report.xls	Xls
	210920_LU02_sabkeller_TC1_Mpos_CC.raw	Raw
	210920_LU02_sabkeller_TC1_Mpos_DMSO.raw	Raw
	210920_LU02_sabkeller_TC2_Mpos_CC.raw	Raw
	210920_LU02_sabkeller_TC2_Mpos_DMSO.raw	Raw

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