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Toxoplsama gondii Cdt1 homolg interactome

ABSTRACT: Toxoplasma endodyogeny is governed by a set of Cdk-related kinases (Crk). In this study we investigated TgCrk4 and its cyclin partner TgCyc4. This complex regulates many cell cycle related processes at the G2 phase. We identified an interactor of this complex TgCdt1 and analyzed its interactome using proteomic studies.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Toxoplasma Gondii Me49

TISSUE(S): Cell Culture

SUBMITTER: Clem Marsilia

LAB HEAD: Elena S. Suvorova

PROVIDER: PXD043924 | Pride | 2024-06-16

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	20230302_RH-KU80-HA_control-1.raw	Raw
	20230302_RH-KU80-HA_control-2.raw	Raw
	20230516_LS_IP_Cdt1-1.raw	Raw
	20230516_LS_IP_Cdt1-2.raw	Raw
	Cdt1_txt.zip	Other

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Publications

The Crk4-Cyc4 complex regulates G<sub>2</sub>/M transition in Toxoplasma gondii.

Hawkins Lauren M LM Wang Chengqi C Chaput Dale D Batra Mrinalini M Marsilia Clem C Awshah Danya D Suvorova Elena S ES

The EMBO journal 20240410 11

A versatile division of apicomplexan parasites and a dearth of conserved regulators have hindered the progress of apicomplexan cell cycle studies. While most apicomplexans divide in a multinuclear fashion, Toxoplasma gondii tachyzoites divide in the traditional binary mode. We previously identified five Toxoplasma CDK-related kinases (Crk). Here, we investigated TgCrk4 and its cyclin partner TgCyc4. We demonstrated that TgCrk4 regulates conventional G<sub>2</sub> phase processes, such as repress ...[more]

PMID: 38600241

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