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Toxoplasma gondii Cyclin-4 Interactome

ABSTRACT: Toxoplasma endodyogeny is governed by a set of Cdk-related kinases (Crk). In this study we investigated TgCrk4 and its cyclin partner TgCyc4. This complex regulates many cell cycle related processes at the G2 phase. To beter undestand the funtion of the TgCrk4/TgCyc4 complex we analyzed the interactome of TgCyc4.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Toxoplasma Gondii Me49

TISSUE(S): Cell Culture

SUBMITTER: Clem Marsilia

LAB HEAD: Elena S. Suvorova

PROVIDER: PXD043994 | Pride | 2024-06-16

REPOSITORIES: Pride

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			Action	DRS
	20210202_RH-TIR-HA_control-1.raw	Raw
	20210202_RH-TIR-HA_control-2.raw	Raw
	20230201_LS_cyclin4-IP_a.raw	Raw
	20230201_LS_cyclin4-IP_b.raw	Raw
	mqpar.xml	Xml

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Publications

The Crk4-Cyc4 complex regulates G<sub>2</sub>/M transition in Toxoplasma gondii.

Hawkins Lauren M LM Wang Chengqi C Chaput Dale D Batra Mrinalini M Marsilia Clem C Awshah Danya D Suvorova Elena S ES

The EMBO journal 20240410 11

A versatile division of apicomplexan parasites and a dearth of conserved regulators have hindered the progress of apicomplexan cell cycle studies. While most apicomplexans divide in a multinuclear fashion, Toxoplasma gondii tachyzoites divide in the traditional binary mode. We previously identified five Toxoplasma CDK-related kinases (Crk). Here, we investigated TgCrk4 and its cyclin partner TgCyc4. We demonstrated that TgCrk4 regulates conventional G<sub>2</sub> phase processes, such as repress ...[more]

PMID: 38600241

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2024-06-16 | PXD043924 | Pride

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Project description:Toxoplasma endodyogeny is governed by a set of Cdk-related kinases (Crk). In this study we investigated TgCrk4 and its cyclin partner TgCyc4. This complex regulates many cell cycle related processes at the G2 phase. To beter undestand the funtion of the TgCrk4/TgCyc4 complex we analyzed the interactome of TgCyc4 and TgCrk4 independanlty.

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