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PKA R-dependent phosphoproteome of T. gondii treated with the phosphodiesterase inhibitor zaprinast

ABSTRACT: Toxoplasma gondii is a ubiquitous pathogen of warm-blooded animals and belongs to the phylum of apicomplexan parasites. Apicomplexans cause diseases of high mortality, including toxoplasmosis, malaria, and cryptosporidiosis. Cyclic nucleotide-dependent protein kinases in this divergent family of parasites play crucial roles in pathogenesis and spread. Here, we conduct a phosphoproteomics experiment after T. gondii parasites are depleted of the protein kinase A regulatory subunit (PKA R), resulting in up-regulation of the PKA catalytic subunit 1 (PKA C1).

INSTRUMENT(S): Orbitrap Exploris 480, FAIMS compensation voltage

ORGANISM(S): Toxoplasma Gondii Rh

SUBMITTER: Alice Herneisen

LAB HEAD: Sebastian Lourido

PROVIDER: PXD044398 | Pride | 2024-07-12

REPOSITORIES: Pride

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			Action	DRS
	20210521_tgALH088_zap_wholeproteome_1.raw	Raw
	20210521_tgALH088_zap_wholeproteome_2_20210522084051.raw	Raw
	20210521_tgALH088_zap_wholeproteome_3_20210522130326.raw	Raw
	20210521_tgALH088_zap_wholeproteome_4_20210522180929.raw	Raw
	20210521_tgALH088_zap_wholeproteome_5_20210522215924.raw	Raw

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PKG-dependent phosphoproteome of T. gondii treated with the phosphodiesterase inhibitor zaprinast

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