PKA R-dependent phosphoproteome of T. gondii treated with the phosphodiesterase inhibitor zaprinast
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ABSTRACT: Toxoplasma gondii is a ubiquitous pathogen of warm-blooded animals and belongs to the phylum of apicomplexan parasites. Apicomplexans cause diseases of high mortality, including toxoplasmosis, malaria, and cryptosporidiosis. Cyclic nucleotide-dependent protein kinases in this divergent family of parasites play crucial roles in pathogenesis and spread. Here, we conduct a phosphoproteomics experiment after T. gondii parasites are depleted of the protein kinase A regulatory subunit (PKA R), resulting in up-regulation of the PKA catalytic subunit 1 (PKA C1).
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Toxoplasma Gondii Rh
SUBMITTER: Alice Herneisen
LAB HEAD: Sebastian Lourido
PROVIDER: PXD044398 | Pride | 2024-07-12
REPOSITORIES: Pride
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