Dataset Information

ITRAQ-based proteomics reveals potential markers and treatment pathways for acute Achilles tendon rupture

ABSTRACT: We used the coupled isobaric tag for relative and absolute quantitation-liquid chromatography-electrospray ionization-tandem mass spectrometry approach to examine protein expression in acute Achilles tendon rupture patients.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Tendon

DISEASE(S): Wounds And Injuries

SUBMITTER: Jiasharete Jielile

LAB HEAD: Jiasharete Jielile

PROVIDER: PXD046451 | Pride | 2024-01-26

REPOSITORIES: Pride

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iTRAQ-based proteomics reveals potential markers and treatment pathways for acute Achilles tendon rupture.

Qianman Bayixiati B Wupuer Aikeremu A Jiasharete Tuomilisi T Luo Biao B Nihemaiti Meihua M Jielile Jiasharete J

Journal of orthopaedic surgery and research 20231109 1

<h4>Background</h4>Due to its limited blood supply and irregular mechanical loading, the Achilles tendon is the most frequently ruptured tendon. Despite the rising incidence of acute Achilles tendon rupture (AATR), the optimal treatment remains controversial. Missed diagnoses and delayed treatments lead to poor outcomes and limited treatment options. This study aimed to identify potential biomarkers for diagnosing and developing therapies for AATR.<h4>Methods</h4>We employed the coupled isobaric ...[more]

PMID: 37946221

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