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Morpholino nicotinamide analogs of ponatinib, dual MNK, p70S6K inhibitors, display efficacy against lung and breast cancers

ABSTRACT: Global and phosphoproteomic analysis to identify and characterize oncogenic pathways differentially regulated by the MNK/p70S6Ki, HSND80

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Breast Cancer

SUBMITTER: Rodrigo Mohallem

LAB HEAD: Herman O.

PROVIDER: PXD057373 | Pride | 2025-03-27

REPOSITORIES: Pride

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			Action	DRS
	PPF-RC-1786_Global-ND80-1_1_A.raw	Raw
	PPF-RC-1786_Global-ND80-2_1_A.raw	Raw
	PPF-RC-1786_Global-ND80-3_1_A.raw	Raw
	PPF-RC-1786_Global-ND80-4_1_A.raw	Raw
	PPF-RC-1786_Global_DM-1_1_A.raw	Raw

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Morpholino nicotinamide analogs of ponatinib, dual MNK, p70S6K inhibitors, display efficacy against lung and breast cancers.

Chaudhuri Riddhi R Dayal Neetu N Kaiser Joshua J Mohallem Rodrigo R Brauer Nickolas R NR Yeboah Kofi Simpa KS Aryal Uma K UK Sintim Herman O HO

Bioorganic chemistry 20250226

Therapeutic options for aggressive cancer types such as breast and lung remain limited; disease relapse and death occur in 30-60% of non-small cell lung cancer (NSCLC) patients, whereas in triple-negative breast cancer or TNBC, recurrence-free survival occurs in less than 30% patients. The kinases, MNK and p70S6K have been proposed as targets for the potential treatment of breast cancer (BC) and lung cancer but currently, no drug that was purposely designed to inhibit these kinases have been app ...[more]

PMID: 40081260

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