Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Dissemination of GIM-1-positive Serratia marcescens in Western Germany

ABSTRACT: Dissemination of GIM-1

PROVIDER: PRJEB15351 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR1616770_1.fastq.gz	Fastqsanger.gz
	ERR1616770_2.fastq.gz	Fastqsanger.gz
	ERR1616780_1.fastq.gz	Fastqsanger.gz
	ERR1616780_2.fastq.gz	Fastqsanger.gz
	ERR1616771_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 26

Similar Datasets

Protracted Regional Dissemination of GIM-1-Producing Serratia marcescens in Western Germany.

Project description:The metallo-beta-lactamase GIM-1 has been found in various bacterial host species nearly exclusively in western Germany. However, not much is known about the epidemiology of GIM-1-positive Serratia marcescens Here we report on a surprisingly protracted regional dissemination. In-hospital transmission was investigated by using conventional epidemiological tools to identify spatiotemporal links. Strain typing was performed using pulsed-field gel electrophoresis (PFGE) and whole-genome sequencing (WGS). Bayesian phylogeny was used to infer the time axis of the observed occurrence. Thirteen S. marcescens strains from 10 patients from 6 different German hospitals were investigated. Suspected in-hospital transmissions were confirmed by molecular typing at a higher resolution by WGS than by PFGE. A detailed sequence analysis demonstrated the spread of one predominant strain variant but also provided evidence for transfer of the blaGIM-1 gene cassette between different strains. A Bayesian phylogenetic analysis showed that the most recent common ancestor of the identified clonal cluster could be dated back to April 1993 (95% highest posterior density interval, January 1973 to March 2003) and that this strain might have already harbored the blaGIM-1 at that time and, therewith, years before the first detection of this resistance gene in clinical specimens. This study shows a long-standing clonal and plasmid-mediated expansion of GIM-1-producing S. marcescens that might have gone unnoticed in the absence of a standardized and effective molecular screening for carbapenemases. The systematic and early detection of resistance is thus highly advisable, especially for the prevention of potentially long-term dissemination that may progress beyond control.

| S-EPMC5328549 | biostudies-literature

Emergence of metallo-β-lactamase GIM-1 in a clinical isolate of Serratia marcescens.

Project description:The metallo-β-lactamase GIM-1 (German imipenemase) has been found so far only in clinical isolates of Pseudomonas aeruginosa from Germany. Here we report the detection of bla(GIM-1) in a clinical strain of Serratia marcescens that was isolated from urine, blood, and wound samples over a period of 20 months. The strain was repeatedly isolated from one patient in two German hospitals and an outpatient department located in the region in which all previously described GIM-1-producing P. aeruginosa strains were identified.

| S-EPMC3421846 | biostudies-literature

Genetic interaction analysis of RSA1 deletion strains (GIM screen)

Project description:A S. cerevisiae strain with deletion of RSA1 gene was combined with two collections of yeast mutants: one in which non-essential genes were deleted and one in which an long 3' UTR extension has been added to the mRNA of essential genes (GIM method, Decourty et al., 2008). Combined double-mutant deletion cells growth was quantified using barcodes that are specific for each gene mutation. A reference population was obtained by mixing the results of 15 GIM screens DNA prior to barcode amplification and labeling (Decourty et al., in preparation). The identification of genetic interactions between deletion of RSA1 and deletion of RTT106, a histone chaperone, indicate a potential role of Rtt106 in snoRNP formation.

2019-10-10 | GSE118550 | GEO

Genetic interaction mapping (GIM) for factors involved in RNA and protein synthesis and degradation

Project description:A S. cerevisiae strain a gene of interest mutated or deleted was combined with two collections of yeast mutants: one in which non-essential genes were deleted and one in which an long 3' UTR extension has been added to the mRNA of essential genes (GIM method, Decourty et al., 2008). Combined double-mutant deletion cells growth was quantified using barcodes that are specific for each gene mutation. A reference population was obtained by mixing the results of 15 GIM screens DNA prior to barcode amplification and labeling (Decourty et al., in preparation). The identification of genetic interactions between genes involved in different cellular pathways indicate new functions for previously characterized genes and new links between

2019-12-31 | GSE119174 | GEO

Piscirickettsia salmonis T-GIM

Project description:Piscirickettsia salmonis T-GIM Transcriptome or Gene expression

| PRJNA413086 | ENA

Piscirickettsia salmonis T-GIM

Project description:Piscirickettsia salmonis T-GIM Genome sequencing and assembly

| PRJNA185169 | ENA

Serratia marcescens BJL200 secretome

Project description:Study the secretome of Serratia marcescens BJL200 upon growth on chitin.

2018-05-30 | PXD005225 | Pride

Piscirickettsia salmonis strain:S-GIM

Project description:Piscirickettsia salmonis strain:S-GIM Transcriptome or Gene expression

| PRJNA413085 | ENA

Piscirickettsia salmonis strain:S-GIM

Project description:Piscirickettsia salmonis strain:S-GIM Genome sequencing and assembly

| PRJNA231165 | ENA

Nuclease overexpression mutants of Serratia marcescens.

Project description:A family of mutants overexpressing the Serratia marcescens extracellular nuclease has been known for decades. A number of these alleles are characterized here at the molecular level, and the mutant genes are identified, yielding a likely model for their phenotype. The known mutations exert their effect indirectly on nucA expression by elevating the basal SOS response of the cell. Mutations have been found in xerC and uvrD, both of which result in partial SOS induction. A classic nucsu allele, that of strain W1050, is also likely to be in xerC.

| S-EPMC107160 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data