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CircAMN1/miR-205_R-1/SLC39A8 axis regulates ferroptosis in endometrial epithelial cells and regulates the occurrence of retained placenta in cows

ABSTRACT: circAMN1/miR-205_R-1/SLC39A8 axis regulates ferroptosis in endometrial epithelial cells and regulates the occurrence of retained placenta in cows

PROVIDER: PRJNA1043590 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26899154.fastq.gz	Fastqsanger.gz
	SRR26899155.fastq.gz	Fastqsanger.gz
	SRR26899156.fastq.gz	Fastqsanger.gz
	SRR26899157.fastq.gz	Fastqsanger.gz
	SRR26899158.fastq.gz	Fastqsanger.gz

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circAMN1/miR-205_R-1/SLC39A8 axis regulates ferroptosis in endometrial epithelial cells and regulates the occurrence of retained placenta in cows

Project description:In this study, we performed RNA-sequencing to characterize the expression profiles of circRNAs in caudal vein blood samples of postpartum Holstein cows whose fetal membranes were discharged normally or retained to identify retained placenta (RP)-related genes and evaluate their molecular mechanisms.

2023-11-24 | GSE248362 | GEO

Transcriptome analyses of intestine-specific Slc39a8-KO mice

Project description:Purpose: To identify genes whose expression was altered in the intestinal epithelial cells (IECs) of Slc39a8-KO mice. Methods: Poly(A) RNA-seq Results: We identified four genes that showed changes in their expression in the Slc39a8-KO IECs.

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Plasma Metabolomics Reveals Pathogenesis of Retained Placenta in Dairy Cows.

Project description:The complex etiology and pathogenesis of retained placenta (RP) bring huge challenges for researchers and clinical veterinarians in investigating the pathogenesis and treatment schedule. This study aims to investigate the pathogenesis of RP in dairy cows by plasma metabolomics. As subjects, 10 dairy cows with RP and 10 healthy dairy cows were enrolled according to strict enrollment criteria. Imbalanced antioxidant capacity, reduced Th1/Th2 cytokine ratio, and deregulation of total bilirubin (T-bil), alkaline phosphatase (ALP), and reproductive hormones were shown in dairy cows with RP by detecting biochemical indicators, oxidation and antioxidant markers, and cytokines in serum. Plasma metabolites were detected and analyzed by a liquid chromatography-mass spectrometry (LC-MS) system coupled with multivariate statistical analysis software. A total of 23 potential biomarkers were uncovered in the plasma of dairy cows with RP. The metabolic pathways involved in these potential biomarkers are interconnected, and the conversion, utilization, and excretion of nitrogen were disturbed in dairy cows with RP. Moreover, these potential biomarkers are involved in the regulation of antioxidant capacity, inflammation, and autocrine or paracrine hormone. All of these findings suggest that an imbalance of these potential biomarkers might be responsible for the imbalanced antioxidant capacity, reduced Th1/Th2 cytokine ratio, and deregulation of reproductive hormones in dairy cows with RP. The regulation of metabolic pathways involved in these potential biomarkers represents a promising therapeutic strategy for RP.

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RNA-seq study on the placentomes collected from the cows with or without retained placenta

Project description:We conducted an RNA-sequencing on the placentomes that were collected from 4 and 3 cows with and without retained placenta, respectively. Placentomes were collected from the cows within 30 minutes after parturition and samples were taken from the feto-maternal junction sites of the placentomes. These samples were used for RNA-sequencing and the results showed 240 genes that were differentially expressed between the two groups. These genes could be candidate genes that are involved in the development of placental retention in cattle.

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RNA-seq analysis of Slc39a8(neo/neo) versus wild-type mice: yolk sac, placenta and fetal liver, kidney, lung, heart and cerebellum

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Project description:RNAseq was performed using cerebellum tissue of WT and neuron-specific slc39a8-KO mice

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Biomarkers for diagnosing the retained placenta in cows-does the analysis of serum proteome keep the secret?

Project description:Retained placenta (RP), a quite common disorder in dairy cows, shows a high negative impact on their health status and milk production. Therefore, the biomarkers indicating the risk for RP could yield benefits in dairy management. The study aimed to investigate the serum proteome as the source of the biomarkers for diagnosing the RP. Using the high-resolution liquid chromatography-tandem mass spectrometry, we compared the composition of serum proteome between 9 cows with the RP and 6 with the physiologic puerperium (PP). Among 651 identified proteins, seven had higher, and three showed lower abundance in RP than in the PP group. The differently abundant proteins participated in 15 pathways: six related to hemostasis, three involved in the lipoprotein metabolism, and the remaining ones associated with redox homeostasis, post-translational modification, scavenging, etc. Validation of the proteomic results, using ELISA and spectrophotometric assays, showed that the two identified proteins, haptoglobin, and lipopolysaccharide-binding protein, could represent reliable RP biomarkers. Our results confirmed that the analysis of serum proteome shed "the light" on the counterparty piece(s) of the RP pathogenesis "puzzle" and could be an efficient "tool" in mining for RP biomarkers.

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The schizophrenia-associated variant in SLC39A8 alters N-glycosylation in the mouse brain

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