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ChIP-seq assay for BRG1 in human SUP-B15 and Nalm-6 cell lines

ABSTRACT: ChIP-seq assay for BRG1 in human SUP-B15 and Nalm-6 cell lines

PROVIDER: PRJNA1049482 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27118149_1.fastq.gz	Fastqsanger.gz
	SRR27118149_2.fastq.gz	Fastqsanger.gz
	SRR27118150_1.fastq.gz	Fastqsanger.gz
	SRR27118150_2.fastq.gz	Fastqsanger.gz
	SRR27118151_1.fastq.gz	Fastqsanger.gz

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ChIP-seq assay for BRG1 in human SUP-B15 and Nalm-6 cell lines

Project description:Abstract: BRG1 is highly expressed in adult B-cells acute lymphoblastic leukemia and is associated with poor prognosis. High expression of BRG1 promotes the proliferation and resistance to apoptosis of B-ALL cells. BRG1 exerts these functions mainly through activation of the PI3K/AKT signaling pathway. In order to understand the specific regulatory mechanism, we used ChIP-seq to detect the DNA fragments bound by BRG1 in SUP-B15 and Nalm-6 cell lines.

2024-09-13 | GSE249559 | GEO

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Project description:The acute lymphoblastic leukemia cells lines JM-1, REH, Nalm-27, and SUP-B15 were analyzed for baseline expression of extacellular matrix and adhesion molecules using a pathway focused cDNA microarray (SABiosciences). RNA isolated from the ALL cell lines JM-1, REH, Nalm-27, and SUP-B15 was analyzed using the Extracellular Matrix and Adhesion Molecules Oligo GEArray (SABIosciences).

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Human SUP-B15 cells: CNV compared to reference genome.

Project description:Copy Number Variaton (CNV) detection of human BCR-ABL positive acute lymphoblastic leukemia (ALL) cell line, SUP-B15.

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Project description:The Philadelphia chromosome (Ph) encodes the oncogenic BCR-ABL1 tyrosine kinase, which defines a subset of acute lymphoblastic leukemia (ALL) with a particularly unfavorable prognosis. In this study, the tyrosine kinase inhibitor imatinib was used for pharmacological inhibition of BCR-ABL1. Gene expression profiles of Ph+ ALL cell lines were analyzed in response to imatinib treatment. Four Ph+ ALL cell lines (BV-173, NALM-1, SUP-B15, and TOM1) were either treated with 10µM STI571 (Imatinib) for 16 hours or cultured in absence of STI571.

2010-09-10 | E-GEOD-23743 | biostudies-arrayexpress

Human SUP-B15 cells: CNV compared to reference genome.

Project description:Human SUP-B15 cells: CNV compared to reference genome.

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Genome-wide assay of BRG1 regulated genes in inflamed colon epithelial cells

Project description:Here we focus on the function of BRG1 in colitis and colitis-associated-cancer, in the aim of finding the direct target genes of BRG1 which may response for the phenotype we observed in BRG1 conditional knock-out mice, ChIP-Seq assay is used. The cells used for ChIP-Seq is colon epithelial cells which isolated from DSS treated mice.

2019-03-01 | GSE112127 | GEO

Nalm 6 WT Nalm6 BKO Nalm 6 A hets

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Stenotrophomonas sp. 1121-B15 isolate:1121-B15

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Protein-protein interactions of BRG1 or BRG1-HSA in SW13 cells

Project description:The SWI/SNF complex remodels chromatin in an ATP-dependent manner through the ATPase subunits BRG1 and BRM. Chromatin remodeling alters nucleosome structure to change gene expression, however aberrant remodeling and gene expression can result in cancer. The function and localization on chromatin of the SWI/SNF complex depends on the protein makeup of the complex. Here we report the protein-protein interactions of wild-type BRG1 or mutant BRG1 in which the HSA domain has been deleted (BRG1-HSA). We demonstrate the interaction of BRG1 with most SWI/SNF complex members and a failure of a number of these members to interact with BRG1-HSA. These results demonstrate that the HSA domain of BRG1 is a critical interaction platform for the correct formation of SWI/SNF remodeling complexes.

2023-02-15 | PXD029647 | Pride

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