Project description:This is the first report evaluating the use of fluorescent imaging to determine the pharmacokinetics, lymphatic uptake, and bioavailability of a near-infrared dye-labeled antibody conjugate. Model is encoded by Matthew Roberts and submitted to BioModels by Krishna Tiwari
Project description:To clarify the effects of near-infrared radiation, we assessed DNA microarray after water-filtered broad-spectrum near-infrared (1100-1800 nm together with a water-filter that excludes wavelengths 1400-1500 nm) irradiation. We performed 5 rounds of near-infrared irradiation (at 10 J âcm2) using 2 sets of transparent polycarbonate plates, one to block UV and the other to block both UV and near-infrared.
Project description:To clarify the effects of near-infrared radiation, we assessed DNA microarray after water-filtered near-infrared (1100-1800 nm together with a water-filter that excludes wavelengths 1400-1500 nm) irradiation.
Project description:To clarify the effects of near-infrared radiation, we assessed DNA microarray after water-filtered broad-spectrum near-infrared (1100-1800 nm together with a water-filter that excludes wavelengths 1400-1500 nm) irradiation.
Project description:Primary objectives: - Evaluate tumour detection sensitivity and specificity with the following image enhancement modalities:
- 1 ‘narrow-band imaging’, 2 ‘autofluorescent imaging’, 3 ‘near-infrared indocyanin green imaging’, 4 ‘5-aminolevulinic acid fluorescent imaging’, 5 ‘three-dimensional imaging’ and 6 ‘spray-dye chromoendoscopy’ compared to conventional white light laparoscopy in patients with peritoneal carcinomatosis in order to achieve best tumour detection.
Primary endpoints: -Evaluate tumour detection sensitivity and specificity with the following image enhancement modalities:
1 ‘narrow-band imaging’, 2 ‘autofluorescent imaging’, 3 ‘near-infrared indocyanin green imaging’, 4 ‘5-aminolevulinic acid fluorescent imaging’, 5 ‘three-dimensional imaging’ and 6 ‘spray-dye chromoendoscopy’ compared to conventional white light laparoscopy in patients with peritoneal carcinomatosis in order to achieve best tumour detection.
Project description:Gold nanorods mediated photothermal therapy represents a promising technique for cancer treatment, utilizing GNRs in conjunction with near-infrared laser irradiation to convert energy into heat. In the present study, we employed PTT to induce apoptosis in pancreatic cancer cells and investigated its underlying mechanisms through quantitative proteomics analysis.
Project description:Interventions: To assess the blood flow at anastomotic site by comparing a direct vision with that under near infrared light after intravenous infusion of indocyanine green.
Primary outcome(s): Is it effective or not to assess blood flow at anastomotic site by indocyanine green fluorescent imaging?
Study Design: Single arm Non-randomized
Project description:Current screening modalities for prostate cancer rely on serologic testing for PSA and transrectal biopsy; however, many prostate cancers behave indolently.Because aggressively growing tumors depend on oncogenic drivers, we hypothesized that we could identify early, but aggressive prostate cancer,by an imaging modality targeting Hsp90, a chaperone for many molecules involved in oncogenic signaling. Previously we observedgreater avidity ofa probe,consisting of a near infrared dye tethered to an Hsp90 inhibitor,for cancers with greatermetastatic potential. We now report that an Hsp90 inhibitor-linked near infrared dye with greater tissue penetration could detect prostate cancers in preclinical models and in a phase I human clinical trial. These data, demonstrating specific uptake into aggressive tumors, in conjunction with our prior observations on photodynamic therapy guided by Hsp90 expression support a theranostic approach todetect and treatearly aggressive prostatecancers.
