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Maternal circadian rhythms and metabolic plasticity in the offspring

ABSTRACT: Maternal circadian rhythms and metabolic plasticity in the offspring

PROVIDER: PRJNA1100524 | ENA |

REPOSITORIES: ENA

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Maternal Circadian Rhythms during Pregnancy Dictate Metabolic Plasticity in Offspring

Project description:Maternal Circadian Rhythms during Pregnancy Dictate Metabolic Plasticity in Offspring

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Maternal circadian rhythms and metabolic plasticity in the offspring

Project description:The impact of maternal circadian disruption during pregnancy on the metabolic outcome in the offspring was explored. To investigate whether epigenetic changes engage in the metabolic plasticity, global patterns of DNA methylation was compared between the control and circadian disruption during pregnancy in the fetal and mouse livers.

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Maternal Circadian Rhythms during Pregnancy Dictate Metabolic Plasticity in Offspring

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Project description:Disruption of circadian rhythm during pregnancy produced adverse health outcomes in offspring. However, the role of maternal circadian rhythms in infants’ immunity and their susceptibility to inflammation remains poorly understood. Here we reported that disruption of circadian rhythms in pregnant mice profoundly aggravated the severity of neonatal inflammatory disorders, including necrotizing enterocolitis (NEC) and sepsis. The diminished production of maternal-derived docosahexaenoic acid (DHA) and the impaired immunosuppressive function of myeloid-derived suppressor cells (MDSCs) in neonates played a dominant role in this process. Mechanistically, DHA enhanced the immunosuppressive function of neonatal MDSCs viaPPARγ mediated mitochondrial oxidative phosphorylation. Transfer of MDSCs or perinatal supplementation of DHA relieved neonatal inflammation induced by maternal rhythms disruption. These observations revealed an important role of maternal circadian rhythms in the control of neonatal inflammation via metabolic reprograming of myeloid cells.

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Gestational chronodisruption throughout pregnancy impairs adipose tissue physiology in the offspring

Project description:Compelling evidence supports that gestational chronodisruption induces major changes in maternal circadian rhythms, fetal development and that these changes impact adult life at many physiological levels. Using a rat model of chronic photoperiod shifting throughout gestation (CPS), we investigated the detrimental effects of gestational CPS on glucose homeostasis, adipose tissue physiology and metabolism in the adult male offspring. At proteomic level, in CPS adipose tissue, 275 proteins displayed differential expression, compared with LD animals fed with a standard diet. Interestingly, CPS offspring and LD fed with HFD showed 20 proteins in common (2 upregulated 18 downregulated). Based on these common proteins, the IPA analysis found that 2 functional pathways were significantly altered; the network 1 (AKT/ERK) and the network 2 (TNF/IL4).

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