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Maternal Circadian Rhythms during Pregnancy Dictate Metabolic Plasticity in Offspring

ABSTRACT: Maternal Circadian Rhythms during Pregnancy Dictate Metabolic Plasticity in Offspring

PROVIDER: PRJNA989240 | ENA |

REPOSITORIES: ENA

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Maternal Circadian Rhythms during Pregnancy Dictate Metabolic Plasticity in Offspring

Project description:The circadian gene expression in peripheral tissue displays rhythmicity which is reprogrammed by feeding rhythms and dietary composition in mammals. In this study, circadian transcriptome was performed to investigate how maternal circadian rhythms during pregnancy influences circadian gene regulation in the mouse liver.

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Project description:16 rats were mated and the dams continued pregnancy (controls) or were subsequently caloric restricted (CR) for 20% during days 1-12. Control female/male offspring continued normal lactation, while offspring of CR-treated dams received either normal lactation (CR group) or received during lactation until PN21 leptin supplementation. Leptin treatment of offspring during lactation after caloric restriction of dams during pregnancy reverts CR-induced dysfunction.

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