Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Aged Mouse Muscle and Serum: Sedentary or Exercised Animals with or without Nicotinamide N-methyltransferase Inhibitor Treatment

ABSTRACT: Aged Mouse Muscle and Serum: Sedentary or Exercised Animals with or without Nicotinamide N-methyltransferase Inhibitor Treatment

PROVIDER: PRJNA1113614 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Aged Mouse Muscle and Serum: Sedentary or Exercised Animals with or without Nicotinamide N-methyltransferase Inhibitor Treatment

Project description:Epigenomic profiling mouse gastrocnemius muscle and serum in aged female mice with/without exercise, with/without nicotinamide N-methyltransferase inhibitor treatment

2024-07-13 | GSE267903 | GEO

Aged Mouse Muscle: Sedentary or Exercised Animals with or without Nicotinamide N-methyltransferase Inhibitor Treatment

Project description:Aged (22-mo) female mice (n=35), obtained from the US NIH National Institute on Aging (NIA) Aged Rodent Colony, were randomly assigned to one of four groups: saline-treated sedentary ( n=9), nicotinamide N-methyltransferase inhibitor (NNMTi)-treated sedentary (10 mg/kg body weight; n=9), saline-treated progressive weighted wheel running (PoWeR; saline; n=10), and NNMTi-treated PoWeR (10 mg/kg body weight; n=7) . Group-housed Sed cohorts were compared to singly-housed PoWeR cohorts that underwent a 1-week introduction to an unweighted wheel, followed by eight weeks of weighted wheel running. Forelimb grip strength was assessed by a single NNMTi treatment-blinded investigator during week six and averaged across 2-4 trials/mouse. At the end of week 8, when mice were ~24.5-months-old, the strength of the right limb plantarflexor muscle complex was measured using an in vivo isometric peak tetanic torque technique and a fatigue test. After the fatigue test, mice were euthanized, and tissues were weighed and collected. Of note, hindlimb muscles from the right limb (the limb that underwent in vivo isometric peak tetanic torque and fatigue testing) were processed for immunohistochemistry to avoid acute effects of muscle functional testing on the proteome and metabolome. Hindlimb muscles from the left limb that did not undergo torque and fatigue testing were flash-frozen for proteome and metabolome analyses.

2024-05-07 | MSV000094700 | MassIVE

miRNA expression data from sedentary and exercised rats

Project description:Loss of skeletal muscle mass during aging, also known as sarcopenia, is a worldwide health problem. The etiology of sarcopenia remains unknown; however, recent studies revealed that sedentarism, fat gain, and epigenetic regulators such as miRNAs are critical regulators in its developing. One effective intervention to prevent and treat sarcopenia is aerobic exercise. We used miRNA microarrays to determine the changes in miRNA expression through time and the differences between sedentary and lifelong exercised rats.

2021-05-24 | GSE175390 | GEO

miRNA expression data from sedentary and exercised rats

Project description:miRNA expression data from sedentary and exercised rats

| PRJNA732210 | ENA

Gene expression profile at single cell level of whole melanoma tumor dissociations taken from sedentary or exercised mice

Project description:Exercise reduces tumor growth in certain models but the mechanisms driving this is unknown. Tumors from sedentary or exercised mice were removed and processed for single cell sequencing to explore transcriptional changes in the tumor microenvironment induced by exercise.

2023-07-01 | GSE208205 | GEO

Single cell RNA sequencing of skeletal muscle endothelial cells in sedentary and exercised mice

Project description:Single cell RNA sequencing of skeletal muscle endothelial cells in sedentary and exercised mice

| PRJNA667253 | ENA

Transcription profiling of rat heart samples from active and sedentary animals

Project description:Cardiac hypertrophy was induced by treadmill running. Sedentary animals served as controls. Gene expression was determined by Affymetrix RGU34A GeneChip's to identify genes with differential expression in an adaptive model of cardiac hypertrophy.

2007-10-11 | E-GEOD-739 | biostudies-arrayexpress

Transcription profiling of human skeletal muscle transcript from trained or sedentary young and old subjects

Project description:Aging is associated with mitochondrial dysfunction and insulin resistance. We conducted a study to determine the role of long-term vigorous endurance exercise on age-related changes in insulin sensitivity and various indices of mitochondrial functions. Experiment Overall Design: Skeletal muscle transcript profiling was done using Vastus Lateralis muscle biopsy samples from 10 young sedentary (YS), 10 older sedentary (OS), 10 young trained (YT) and 10 older trained (OT) men and women. Note that YT2, YS1, and OT1 didn't pass the Quality Control Step of dChip (high array/single outliers). Sedentary subjects exercised less than 30 min/day, twice per week. Trained subjects performed â¥ 1 hour cycling or running 6 days/week over the past 4 years.

2008-06-16 | E-GEOD-9103 | biostudies-arrayexpress

Gene expression profile at single cell level of whole melanoma tumor dissociations taken from sedentary or exercised mice

Project description:Gene expression profile at single cell level of whole melanoma tumor dissociations taken from sedentary or exercised mice

| PRJNA858777 | ENA

H_Alessio_05: sedentary and active lifestyles

Project description:The interaction of genetics and environment play a major role in health and disease. Therefore, modeling experiments to investigate gene-environment interaction in a laboratory setting would provide the opportunity to gain mechanistic insight under controlled conditions. In laboratory research it is unclear if the gene-environment interaction of a sedentary lifestyle predisposes laboratory animals to hypokinetic diseases. Keywords: repeat sample

2005-06-24 | GSE2690 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data