Mus musculus
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA210763 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Runx3 function in splenic NK cells
2015-07-13 | E-GEOD-50123 | ExpressionAtlas
Project description:Runx3 function in CD8+ splenic T cells
2015-07-13 | E-GEOD-50119 | ExpressionAtlas
Project description:Cellular binary fate decisions require the progeny to silence genes associated with the alternative fate. The major subsets of alpha:beta T cells have been extensively studied as a model system for fate decisions. While the transcription factor RUNX3 is required for the initiation of Cd4 silencing in CD8 T cell progenitors, it is not required to maintain the silencing of Cd4 and other helper T lineage genes. The other runt domain containing protein, RUNX1, silences Cd4 in an earlier T cell progenitor, but this silencing is reversed whereas the gene silencing after RUNX3 expression is not reverse. Therefore, we hypothesized that RUNX3 and not RUNX1 recruits other factors that maintains the silencing of helper T lineage genes in CD8 T cells. To this end, we performed a proteomics screen of RUNX1 and RUNX3 to determine candidate silencing factors.
2019-11-12 | PXD007511 | Pride
Project description:Runx3 function in IL-2-activated splenic CD8+ T cells
2015-07-13 | E-GEOD-50121 | ExpressionAtlas
Project description:Runx3 function in splenic NK cells (IL-2 or IL-15)
2015-07-13 | E-GEOD-50122 | ExpressionAtlas
Project description:Genome-wide maps of Runx3 bound regions in CD4 splenic dendritic cells.
| PRJNA210764 | ENA
Project description:Runx3 function in splenic NK cells activated in vivo by IL-15.
2015-07-13 | E-GEOD-50120 | ExpressionAtlas
Project description:CD4+ dendritic cells are part of the innate immunity essential for priming and activating of CD4+ T cells To identify Runx3 responsive genes CD4+ dendritic cells were sorted from freshly isolated macs enriched splenic DCs taken from 6 weeks old mice. Six samples from six mice were sorted and analyzed where in each littermates pair consisted of a control and Runx3 KO.
2014-06-22 | E-GEOD-48589 | biostudies-arrayexpress