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Homo sapiens

ABSTRACT: Knock-down of Ror1 in MDA-MB-231 cell line decreases cell invasiveness

PROVIDER: PRJNA379273 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5345320.fastq.gz	Fastqsanger.gz
	SRR5345315.fastq.gz	Fastqsanger.gz
	SRR5345316.fastq.gz	Fastqsanger.gz
	SRR5345317.fastq.gz	Fastqsanger.gz
	SRR5345318.fastq.gz	Fastqsanger.gz

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Knock-down of Ror1 in MDA-MB-231 cell line decreases cell invasiveness

Project description:RNA-Seq profiling of triple-negative MDA-MB-231 cell line with know-down of non-canonical WNT signaling receptor Ror1. The MDA-MB231 cells were either transfected with a non-sense control shRNA (shCTL) or with a ROR1 shRNA (shROR1) construct. The objective was to find expression-responsive targets of these perturbations as potential drivers of MDA-MB231 cell invasiveness.

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Homo sapiens strain:MDA-MB-231

Project description:MDA-MB-231 cell line transcriptome

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Gene expression analysis of MDA MB 231 basal type breast cancer cells with shRNA mediated control (GFP) or ZEB1 knockdown

Project description:Epithelial-to-mesenchymal transition (EMT) is a fundamental process in development and disease. If aberrantly activated it is a trigger for tumour progression and metastasis (Thiery et al 2009 Cell). It is now known that EMT activation is also associated with the maintenance of stem-cell properties (Mani et al. 2008 Cell). Since Zinc-finger enhancer binding transcription factor 1 (ZEB1) is a crucial EMT activator, we analyzed the changes in the gene expression profile that accompany shRNA mediated loss of ZEB1 in MDA MB 231 basal type breast cancer cells. MDA MB 231 is a cell line that exhibits mesenchymal characteristics, but reverts to an epithelial phenotype upon ZEB1 knock down (Spaderna et al. 2008 Cancer Research). MDA MB 231 cells were stably transfected with control (GFP) or ZEB1 shRNA. Upon puromycin selection, single cell clones were picked and characterized. Cells from two control versus two ZEB1 knockdown clones were harvested, total RNA was isolated and processed to hybridization.

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Project description:siRNA-mediated HNRPA2B1 knock-down in MDA-MB-231 cells

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Project description:Expression data from ELK3 knocked down MDA-MB-231 cell line.

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