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Mettl3 regulates late-stage retinogenesis and mouse retina m6A epitranscriptome

ABSTRACT: Mettl3 regulates late-stage retinogenesis and mouse retina m6A epitranscriptome

PROVIDER: PRJNA749616 | ENA |

REPOSITORIES: ENA

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Mettl3 regulates late-stage retinogenesis

Project description:To study the function of Mettl3 during retinal development, we used Six3-Cre and Mettl3floxed mice to conditionally knock out Mettl3 from retinal progenitor cells. The mutant mice show defects in late-stage retinogenesis and structural and physiological homeostasis of the retina.

2022-12-03 | GSE180813 | GEO

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Project description:Mettl3 regulates late retinogenesis

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Mettl3 regulates late-stage retinogenesis and mouse retina m6A epitranscriptome

Project description:This SuperSeries is composed of the SubSeries listed below.

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neonatal and adult mouse retina m6A epitranscriptome [meRIP-seq]

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Project description:neonatal and adult mouse retina m6A epitranscriptome [meRIP-seq]

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Proteomic raw data for Mettl3 Ctrl and RKO mice

Project description:The purpose of this project is to explore the changes in signaling pathways after Mettl3 knockout, and to identify potential downstream target proteins of Mettl3 along with the signaling pathways they are involved in. Ultimately elucidating the molecular mechanisms underlying Mettl3 pathogenesis. Retina of control and Mettl3 knockout mice were collected, and samples were then used for proteomic analysis. After tissue collection, a series of cutting-edge technologies, including protein extraction, enzyme digestion, liquid chromatography-tandem mass spectrometry, and bioinformatics analysis, were employed to investigate the quantitative proteome of the samples.

2024-10-12 | PXD056750 | Pride

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