Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Exploring the molecular mechanism of Bushen Huoxue Fang on premature ovarian failure based on transcriptomics and systems biology

ABSTRACT: Exploring the molecular mechanism of Bushen Huoxue Fang on premature ovarian failure based on transcriptomics and systems biology

PROVIDER: PRJNA897894 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR22178000_1.fastq.gz	Fastqsanger.gz
	SRR22178000_2.fastq.gz	Fastqsanger.gz
	SRR22178001_1.fastq.gz	Fastqsanger.gz
	SRR22178001_2.fastq.gz	Fastqsanger.gz
	SRR22178002_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Exploring the molecular mechanism of Bushen Huoxue Fang on premature ovarian failure based on transcriptomics and systems biology

Project description:Objective: To Explore the mechanism of autophagy in mice with immune premature ovarian failure (POF) and the effect of Bushen Huoxue Fang (BSHXF) Method: POF mice were treated with BSHXF, and estradiol valerate. Then, the ovaries were used for transcriptome sequencing.

2023-04-21 | GSE217193 | GEO

Anopheles funestus FANG colony RNAseq

Project description:Anopheles funestus FANG colony RNAseq

| PRJEB10294 | ENA

Systems biology of prostate cancer

Project description:Systems biology of prostate cancer

| PRJEB34826 | ENA

Novel transcriptomic signatures associated with premature kidney allograft failure

Project description:Novel transcriptomic signatures associated with premature kidney allograft failure

| PRJNA923707 | ENA

Systems biology approaches reveal low-dose effects of nanoparticles

Project description:Here, we show that systems biology approaches can uncover mechanisms underlying cellular responses to nanomaterials. Using RNA Seq, we found that cationic nanoparticles are capable of triggering down-regulation of cell cycle-related genes in primary human bronchial epithelial cells at doses that do not elicit acute cytotoxicity. Bioinformatics analyses implicated NF-kappaB as a putative transcriptional regulator and functional assays confirmed that cationic nanoparticles caused NF-kappaB-dependent cell cycle arrest. Our study demonstrates the feasibility of applying systems biology tools to assess cellular responses to nanomaterials, not least at low doses.

2015-01-17 | E-MTAB-2397 | biostudies-arrayexpress

Systems biology of vaccination for seasonal influenza in humans

Project description:Systems biology of vaccination for seasonal influenza in humans

| PRJNA141363 | ENA

Systems biology approaches reveal low-dose effects of nanoparticles

Project description:Systems biology approaches reveal low-dose effects of nanoparticles

| PRJEB8224 | ENA

Integrated systems-biology platform for power-to-gas technology

Project description:Integrated systems-biology platform for power-to-gas technology

| PRJNA902403 | ENA

Spatially exploring RNA biology in archival formalin-fixed paraffin-embedded tissues

Project description:The capability to spatially explore RNA biology in formalin-fixed paraffin-embedded (FFPE) tissues holds transformative potential for histopathology research. Here, we present pathology-compatible deterministic barcoding in tissue (Patho-DBiT) by combining in situ polyadenylation and computational innovation for spatial whole transcriptome sequencing, tailored to probe the diverse RNA species in clinically archived FFPE samples. It permits spatial co-profiling of gene expression and RNA processing, unveiling region-specific splicing isoforms, and high-sensitivity transcriptomic mapping of clinical tumor FFPE tissues stored for five years. Furthermore, genome-wide single nucleotide RNA variants can be captured to distinguish malignant subclones from non-malignant cells in human lymphomas. Patho-DBiT also maps microRNA regulatory networks and RNA splicing dynamics, decoding their roles in spatial tumorigenesis. Cellular-level Patho-DBiT dissects the spatiotemporal cellular dynamics driving tumor clonal architecture and progression. Patho-DBiT stands poised as a valuable platform to unravel rich RNA biology in FFPE tissues to aid in clinical pathology evaluation.

2024-08-12 | GSE274641 | GEO

Genetic Endothelial Systems Biology of Sickle Stroke Risk

Project description:Genetic differences in endothelial biology could underlie development of phenotypic heterogeneity amongst individuals afflicted with vascular diseases. We obtained BOEC (blood outgrowth endothelial cells) from 20 subjects with sickle cell anemia (age 4-19) shown to be either at-risk (n=11) or not-at-risk (n=9) for ischemic stroke due to, respectively, having or not having occlusive disease at the Circle of Willis (CoW). Gene expression profiling identified no significant single gene differences between the two groups, as expected. However, analysis of Biological Systems Scores, using gene sets that were pre-determined to survey each of nine biological systems, showed that only changes in inflammation signaling are characteristic of the at-risk subjects, as supported by multiple statistical approaches Keywords: disease status analysis

2007-12-18 | GSE9877 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data