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ABSTRACT: Lactobacillus strains for vitamin B12 producing

PROVIDER: PRJNA926949 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR23493800_1.fastq.gz	Fastqsanger.gz
	SRR23493800_2.fastq.gz	Fastqsanger.gz
	SRR23493801_1.fastq.gz	Fastqsanger.gz
	SRR23493801_2.fastq.gz	Fastqsanger.gz

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Effect of amino acid availability on vitamin B12 production in Lactobacillus reuteri

Project description:Recent functional genomics and genome-scale modeling approaches indicated that B12 production in Lactobacillus reuteri could be improved by medium optimization. Here we show that a series of systematic single amino acid omissions could significantly modulate the production of B12 from nearly undetectable levels (by isoleucine omission) to 20-fold higher than previously reported through omission of cysteine. We analyzed by cDNA microarray experiments the transcriptional response of L. reuteri to the medium lacking cysteine. These results supported the observed high B12 production and provided new avenues for future improvement of production of vitamin B12. Keywords: cell type comparison loop design

2010-05-17 | E-GEOD-13391 | biostudies-arrayexpress

Effect of amino acid availability on vitamin B12 production in Lactobacillus reuteri

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PocR regulates glycerol reduction, assembly of metabolosomes and vitamin B12 biosynthesis in Lactobacillus reuteri F275

Project description:Lactobacillus reuteri has been shown to encode a vitamin B12 biosynthesis pathway that is phylogenetically related to the one present in some representatives of gamma-proteobacteria such as Salmonella and Yersinia. Here we present evidence supporting that the similarities between these otherwise unrelated organisms extend to their regulatory mechanisms. Keywords: cell type comparison Loop design

2010-05-17 | E-GEOD-13289 | biostudies-arrayexpress

PocR regulates glycerol reduction, assembly of metabolosomes and vitamin B12 biosynthesis in Lactobacillus reuteri F275

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C. elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor: RNA-seq dataset 2

Project description:Vitamin B12 is an essential micronutrient that functions in two metabolic pathways: the canonical propionate breakdown pathway and the methionine/S-adenosylmethionine (Met/SAM) cycle. In Caenorhabditis elegans, low vitamin B12, or genetic perturbation of the canonical propionate breakdown pathway results in propionate accumulation and the transcriptional activation of a propionate shunt pathway. This propionate-dependent mechanism requires nhr-10 and is referred to as “B12-mechanism-I”. Here, we report that vitamin B12 represses the expression of Met/SAM cycle genes by a propionate-independent mechanism we refer to as “B12-mechanism-II”. This mechanism is activated by perturbations in the Met/SAM cycle, genetically or due to low dietary vitamin B12. B12-mechanism-II requires nhr-114 to activate Met/SAM cycle gene expression, the vitamin B12 transporter, pmp-5, and adjust influx and efflux of the cycle by activating msra-1 and repressing cbs-1, respectively. Taken together, Met/SAM cycle activity is sensed and transcriptionally adjusted to be in a tight metabolic regime.

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C. elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor: RNA-seq dataset 1

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Project description:Food quality improvement through vitamin B12-producing bacteria.

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Mutations of the selected strain growing in low levels of Vitamin B12 in Mycobacterium marinum

Project description:Vitamin B12 (B12) is an important cofactor in mycobacterial metabolism, and some pathogenic mycobacteria need to obtain it from the host. In this study, we investigated the transport of vitamin B12 in Mycobacterium marinum. We identified a transcriptor regulator that could be potentially involved in the uptake process. RNA sequencing analysis were performed in order to elucidate the regulon of this new transcriptor.

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ChIPSeq of H3k36me3 samples of OSKM reprogramming mouse embryonic fibroblasts treated with B12

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