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Effect of IL-15 dose on cultured splenic NK cells [ATAC-seq]

ABSTRACT: Effect of IL-15 dose on cultured splenic NK cells [ATAC-seq]

PROVIDER: PRJNA947199 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23934024_1.fastq.gz	Fastqsanger.gz
	SRR23934024_2.fastq.gz	Fastqsanger.gz
	SRR23934025_1.fastq.gz	Fastqsanger.gz
	SRR23934025_2.fastq.gz	Fastqsanger.gz
	SRR23934026_1.fastq.gz	Fastqsanger.gz

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Effect of IL-15 dose on cultured splenic NK cells [ATAC-seq]

Project description:We cultured splenic NK cells in either low (10 ng/ml) or high (100 ng/ml) doses of IL-15 for ~72 hours. We then performed ATAC-seq to compare differentially accessible regions.

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Effect of IL-15 culture +/- anti-NK1.1 stimulation on splenic NK cells [mNK_IL-15_RNA-seq]

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Genome-wide maps of Runx3 bound regions in splenic NK cells activated in vivo with IL-15

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Project description:NK cells are innate immune cells that recognize and kill foreign, virally-infected and tumor cells without the need for prior immunization. NK expansion following viral infection is IL-2 or IL-15-dependent. To identify Runx3 responsive genes, NK cells were isolated from spleen of WT and Runx3-/- mice . Ten samples (5 WT and 5 Runx3-/-) of freshly isolated NK cells were separately obtained from individual mice. Cells were cultured for 7 days with IL-2 or IL-15.

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RNA squencing of human NK cells activated with IL-15 or IL-12, IL-15, and IL-18

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Runx3 function in splenic NK cells activated in vivo by IL-15.

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2014-01-22 | E-GEOD-50120 | biostudies-arrayexpress

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