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DNA methylation changes in mice induced by mock parabiosis

ABSTRACT: DNA methylation changes in mice induced by mock parabiosis

PROVIDER: PRJNA991712 | ENA |

REPOSITORIES: ENA

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DNA methylation changes in mice induced by mock parabiosis

Project description:Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation and loss of function, leading to increases in morbidity and mortality. However, recent in vitro studies have raised the possibility of age reversal. We characterized several models in which biological age, assessed primarily through analysis of DNA methylation, undergoes reversible changes. Heterochronic parabiosis is one such example.

2023-07-06 | GSE236617 | GEO

DNA methylation changes in mice induced by parabiosis and recovery [HorvathMammalMethylChip40]

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DNA methylation changes in mice induced by parabiosis and recovery [HorvathMammalMethylChip40]

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DNA methylation changes in mice induced by parabiosis and recovery [RRBS]

Project description:DNA methylation changes in mice induced by parabiosis and recovery [RRBS]

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DNA methylation and gene expression changes in mice induced by parabiosis and recovery

Project description:DNA methylation and gene expression changes in mice induced by parabiosis and recovery

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DNA methylation changes in mice induced by parabiosis and recovery [RRBS]

Project description:Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation and loss of function, leading to increases in morbidity and mortality. However, recent in vitro studies have raised the possibility of age reversal. We characterized several models in which biological age is perturbed. Heterochronic parabiosis and recovery from this procedure is one such example.

2023-04-21 | GSE224442 | GEO

Gene expression changes in mice induced by parabiosis and recovery [RNA-seq]

Project description:Gene expression changes in mice induced by parabiosis and recovery [RNA-seq]

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Gene expression changes in mice induced by parabiosis and recovery [RNA-seq]

Project description:Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation and loss of function, leading to increases in morbidity and mortality. However, recent in vitro studies have raised the possibility of age reversal. We characterized several models in which biological age is perturbed. Heterochronic parabiosis and recovery from this procedure is one such example.

2023-04-21 | GSE224378 | GEO

Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types

Project description:Aging is a complex process involving transcriptomic changes associated with deterioration across multiple tissues and organs, including the brain. Recent studies using heterochronic parabiosis have shown that various aspects of aging-associated decline are modifiable or even reversible. To better understand how this occurs, we performed single-cell transcriptomic profiling of young and old mouse brains following parabiosis. For each cell type, we catalogued alterations in gene expression, molecular pathways, transcriptional networks, ligand-receptor interactions, and senescence status. Our analyses identified gene signatures demonstrating that heterochronic parabiosis regulates several hallmarks of aging in a cell-type-specific manner. Brain endothelial cells were found to be especially malleable to this intervention, exhibiting dynamic transcriptional changes that affect vascular structure and function. These findings suggest novel strategies for slowing deterioration and driving regeneration in the aging brain through approaches that do not rely on disease-specific mechanisms or actions of individual circulating factors.

2023-01-14 | GSE222510 | GEO

Estrogen Induced DNA Methylation Changes in Mouse Hippocampus

Project description:Estrogen, specifically estradiol, has been shown to mediate DNA methylation changes at mutiple locations downstream of estrogen response elements (EREs). We identified differentially methylated regions associated with long-term estradiol exposure in the hippocampus of C57BL/6J mice. Hippocampus was collected from ovariectomized (OVX) C57BL/6J mice treated with estradiol (n=5) and vehicle controls (n=5). Genomic DNA was extracted and treated with methylation sensitive restriction enzymes HpaII and HinP1I to enrich for the unmethylated fraction. This fraction was interrogated using the Affymetrix GeneChip® Mouse Tiling Promoter 1.0R Array

2013-05-24 | E-GEOD-43460 | biostudies-arrayexpress

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