Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: George Garinis
PROVIDER: E-MEXP-1503 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Schumacher Björn B van der Pluijm Ingrid I Moorhouse Michael J MJ Kosteas Theodore T Robinson Andria Rasile AR Suh Yousin Y Breit Timo M TM van Steeg Harry H Niedernhofer Laura J LJ van Ijcken Wilfred W Bartke Andrzej A Spindler Stephen R SR Hoeijmakers Jan H J JH van der Horst Gijsbertus T J GT Garinis George A GA
PLoS genetics 20080815 8
Mutant dwarf and calorie-restricted mice benefit from healthy aging and unusually long lifespan. In contrast, mouse models for DNA repair-deficient progeroid syndromes age and die prematurely. To identify mechanisms that regulate mammalian longevity, we quantified the parallels between the genome-wide liver expression profiles of mice with those two extremes of lifespan. Contrary to expectation, we find significant, genome-wide expression associations between the progeroid and long-lived mice. S ...[more]