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Transcription profiling of prop-1 and Ghrhr mutations in gene expression during normal aging in mice (Ames dwarf and Little mice)

ABSTRACT: Effects of the prop-1 and Ghrhr mutations in gene expression during normal aging in mice.

ORGANISM(S): Mus musculus

SUBMITTER: Daniel Amador-Noguez

PROVIDER: E-MEXP-153 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression profile of long-lived Ames dwarf mice and Little mice.

Amador-Noguez Daniel D Yagi Kazuo K Venable Susan S Darlington Gretchen G

Aging cell 20041201 6

Ames dwarf mice (Prop1df/df) and Little mice (Ghrhrlit/lit) are used as models of delayed aging and show significant increases in lifespan (50% and 25%, respectively) when compared with their wild-type siblings. To gain further insight into the molecular basis for the extended longevity of these mice, we used oligonucleotide microarrays to measure levels of expression of over 14 000 RNA transcripts in liver during normal aging at 3, 6, 12 and 24 months. We found that the Prop1df/df and Ghrhrlit/ ...[more]

PMID: 15569359

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