Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of prop-1 and Ghrhr mutations in gene expression during normal aging in mice (Ames dwarf and Little mice)


ABSTRACT: Effects of the prop-1 and Ghrhr mutations in gene expression during normal aging in mice.

ORGANISM(S): Mus musculus

SUBMITTER: Daniel Amador-Noguez 

PROVIDER: E-MEXP-153 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

Gene expression profile of long-lived Ames dwarf mice and Little mice.

Amador-Noguez Daniel D   Yagi Kazuo K   Venable Susan S   Darlington Gretchen G  

Aging cell 20041201 6


Ames dwarf mice (Prop1df/df) and Little mice (Ghrhrlit/lit) are used as models of delayed aging and show significant increases in lifespan (50% and 25%, respectively) when compared with their wild-type siblings. To gain further insight into the molecular basis for the extended longevity of these mice, we used oligonucleotide microarrays to measure levels of expression of over 14 000 RNA transcripts in liver during normal aging at 3, 6, 12 and 24 months. We found that the Prop1df/df and Ghrhrlit/  ...[more]

Similar Datasets

2005-05-30 | E-MEXP-347 | biostudies-arrayexpress
2009-10-31 | E-MTAB-46 | biostudies-arrayexpress
2011-06-25 | E-MEXP-3016 | biostudies-arrayexpress
2021-08-06 | PXD025725 | Pride
2005-10-01 | E-MEXP-354 | biostudies-arrayexpress
2011-12-22 | E-GEOD-29985 | biostudies-arrayexpress
2012-04-02 | E-GEOD-31386 | biostudies-arrayexpress
2011-06-25 | E-MEXP-3017 | biostudies-arrayexpress
2011-06-26 | E-MEXP-3020 | biostudies-arrayexpress
2008-04-16 | E-MEXP-1565 | biostudies-arrayexpress