Dataset Information
Expression profiling, siRNA mediated knockdown of PPARbeta/delta and HSP27 it HeLa cells under IL1b stimulation
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo_sapiens
SUBMITTER: Florian Finkernagel
PROVIDER: E-MTAB-1212 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Regulation of TAK1/TAB1-mediated IL-1β signaling by cytoplasmic PPARβ/δ.
PloS one 20130430 4
The peroxisome proliferator-activated receptor subtypes PPARα, PPARβ/δ, PPARγ are members of the steroid hormone receptor superfamily with well-established functions in transcriptional regulation. Here, we describe an unexpected cytoplasmic function of PPARβ/δ. Silencing of PPARβ/δ expression interferes with the expression of a large subset of interleukin-1β (IL-1β)-induced target genes in HeLa cells, which is preceded by an inhibition of the IL-1β-induced phosphorylation of TAK1 and its downstr ...[more]
