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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Comparative genomic hybridization of DNA from two recently divergent mouse strains, 12925 and C57BL/6J

ABSTRACT: We have performed CGH analysis using 129S5 DNA competitively hybridised with C57BL/6J DNA to RPCI-23 (C57BL/6J) BAC clones spotted at 1Mb resolution (array protocol 7769)

ORGANISM(S): Mus musculus

SUBMITTER: David Adams

PROVIDER: E-MEXP-298 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Complex haplotypes, copy number polymorphisms and coding variation in two recently divergent mouse strains.

Adams David J DJ Dermitzakis Emmanouil T ET Cox Tony T Smith James J Davies Rob R Banerjee Ruby R Bonfield James J Mullikin James C JC Chung Yeun Jun YJ Rogers Jane J Bradley Allan A

Nature genetics 20050424 5

Inbred mouse strains provide the foundation for mouse genetics. By selecting for phenotypic features of interest, inbreeding drives genomic evolution and eliminates individual variation, while fixing certain sets of alleles that are responsible for the trait characteristics of the strain. Mouse strains 129Sv (129S5) and C57BL/6J, two of the most widely used inbred lines, diverged from common ancestors within the last century, yet very little is known about the genomic differences between them. B ...[more]

PMID: 15852006

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