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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of S. cerevisiae single transcription factor deletions

ABSTRACT: Study expression effects of single transcription factor deletions.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: H. Craig Mak

PROVIDER: E-MEXP-351 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Validation and refinement of gene-regulatory pathways on a network of physical interactions.

Yeang Chen-Hsiang CH Mak H Craig HC McCuine Scott S Workman Christopher C Jaakkola Tommi T Ideker Trey T

Genome biology 20050701 7

As genome-scale measurements lead to increasingly complex models of gene regulation, systematic approaches are needed to validate and refine these models. Towards this goal, we describe an automated procedure for prioritizing genetic perturbations in order to discriminate optimally between alternative models of a gene-regulatory network. Using this procedure, we evaluate 38 candidate regulatory networks in yeast and perform four high-priority gene knockout experiments. The refined networks suppo ...[more]

PMID: 15998451

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