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Ontogeny of erythroid lineage differentiation

ABSTRACT: Delineate gene anatomy of differentiating primary primitive and definitive RBCs

ORGANISM(S): Mus musculus

SUBMITTER: James Palis

PROVIDER: E-MTAB-1035 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Ontogeny of erythroid gene expression.

Kingsley Paul D PD Greenfest-Allen Emily E Frame Jenna M JM Bushnell Timothy P TP Malik Jeffrey J McGrath Kathleen E KE Stoeckert Christian J CJ Palis James J

Blood 20121212 6

Erythroid ontogeny is characterized by overlapping waves of primitive and definitive erythroid lineages that share many morphologic features during terminal maturation but have marked differences in cell size and globin expression. In the present study, we compared global gene expression in primitive, fetal definitive, and adult definitive erythroid cells at morphologically equivalent stages of maturation purified from embryonic, fetal, and adult mice. Surprisingly, most transcriptional complexi ...[more]

PMID: 23243273

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