Unknown,Transcriptomics,Genomics,Proteomics

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High-resolution methylation profiling of glioblastoma neural stem cells and reprogrammed derivatives

ABSTRACT: Glioblastoma-derived neural stem (GNS) cells were reprogrammed to induced pluripotent stem (iPS) cells by transgenic expression of OCT4 and KLF4. Genome-wide DNA methylation status was profiled at 485,000 loci to assess epigenetic erasure and restoration due to reprogramming and redifferentiation to the neural stem (NS) cell state.

ORGANISM(S): Homo sapiens

DISEASE(S): glioblastoma multiforme

SUBMITTER: Paul Bertone 

PROVIDER: E-MTAB-1274 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner.

Stricker Stefan H SH   Feber Andrew A   Engström Pär G PG   Carén Helena H   Kurian Kathreena M KM   Takashima Yasuhiro Y   Watts Colin C   Way Michael M   Dirks Peter P   Bertone Paul P   Smith Austin A   Beck Stephan S   Pollard Steven M SM  

Genes & development 20130301 6

Epigenetic changes are frequently observed in cancer. However, their role in establishing or sustaining the malignant state has been difficult to determine due to the lack of experimental tools that enable resetting of epigenetic abnormalities. To address this, we applied induced pluripotent stem cell (iPSC) reprogramming techniques to invoke widespread epigenetic resetting of glioblastoma (GBM)-derived neural stem (GNS) cells. GBM iPSCs (GiPSCs) were subsequently redifferentiated to the neural  ...[more]

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