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MicroRNA expression profiling of normal and glioblastoma-derived neural stem cells

ABSTRACT: MicroRNA analysis of glioblastoma-derived neural stem (GNS) cells performed in parallel with normal neural stem (NS) cell lines

ORGANISM(S): Homo sapiens

SUBMITTER: Paul Bertone

PROVIDER: E-MTAB-3865 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Glioblastoma Stem Cells Respond to Differentiation Cues but Fail to Undergo Commitment and Terminal Cell-Cycle Arrest.

Carén Helena H Stricker Stefan H SH Bulstrode Harry H Gagrica Sladjana S Johnstone Ewan E Bartlett Thomas E TE Feber Andrew A Wilson Gareth G Teschendorff Andrew E AE Bertone Paul P Beck Stephan S Pollard Steven M SM

Stem cell reports 20151101 5

Glioblastoma (GBM) is an aggressive brain tumor whose growth is driven by stemcell-like cells. BMP signaling triggers cell-cycle exit and differentiation of GBM stemcells (GSCs) and, therefore, might have therapeutic value. However, the epigenetic mechanisms that accompany differentiation remain poorly defined. It is also unclear whether cell-cycle arrest is terminal. Herewe find only a subset ofGSCcultures exhibit astrocyte differentiation in response to BMP. Although overtly differentiated non ...[more]

PMID: 26607953

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