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Comparative genomic hybridization by array of glioblastoma-derived neural stem cells

ABSTRACT: Comparative genomic hybridization of glioma neural stem cells and normal human reference DNA

ORGANISM(S): Homo sapiens

DISEASE(S): Giant Cell Glioblastoma

SUBMITTER: Paul Bertone

PROVIDER: E-MTAB-972 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Digital transcriptome profiling of normal and glioblastoma-derived neural stem cells identifies genes associated with patient survival.

Engström Pär G PG Tommei Diva D Stricker Stefan H SH Ender Christine C Pollard Steven M SM Bertone Paul P

Genome medicine 20121009 10

<h4>Background</h4>Glioblastoma multiforme, the most common type of primary brain tumor in adults, is driven by cells with neural stem (NS) cell characteristics. Using derivation methods developed for NS cells, it is possible to expand tumorigenic stem cells continuously in vitro. Although these glioblastoma-derived neural stem (GNS) cells are highly similar to normal NS cells, they harbor mutations typical of gliomas and initiate authentic tumors following orthotopic xenotransplantation. Here, ...[more]

PMID: 23046790

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