Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Methylation profiling of glioblastoma neural stem cells and reprogrammed derivatives

ABSTRACT: Glioblastoma-derived neural stem (GNS) cells were reprogrammed to induced pluripotent stem (iPS) cells by transgenic expression of OCT4 and KLF4. Genome-wide DNA methylation status was profiled at 27,578 CpG sites to assess epigenetic erasure and restoration due to reprogramming and redifferentiation to the neural stem (NS) cell state.

ORGANISM(S): Homo sapiens

DISEASE(S): glioblastoma multiforme

SUBMITTER: Paul Bertone 

PROVIDER: E-MTAB-1275 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner.

Stricker Stefan H SH   Feber Andrew A   Engström Pär G PG   Carén Helena H   Kurian Kathreena M KM   Takashima Yasuhiro Y   Watts Colin C   Way Michael M   Dirks Peter P   Bertone Paul P   Smith Austin A   Beck Stephan S   Pollard Steven M SM  

Genes & development 20130301 6

Epigenetic changes are frequently observed in cancer. However, their role in establishing or sustaining the malignant state has been difficult to determine due to the lack of experimental tools that enable resetting of epigenetic abnormalities. To address this, we applied induced pluripotent stem cell (iPSC) reprogramming techniques to invoke widespread epigenetic resetting of glioblastoma (GBM)-derived neural stem (GNS) cells. GBM iPSCs (GiPSCs) were subsequently redifferentiated to the neural  ...[more]

Similar Datasets

Transcriptomics High-resolution methylation profiling of glioblastoma neural stem cells and reprogrammed derivatives
2013-03-15 | E-MTAB-1274 | biostudies-arrayexpress
Transcriptomics Digital expression analysis of glioma neural stem cells
2012-09-21 | E-MTAB-971 | biostudies-arrayexpress
Transcriptomics Comparative genomic hybridization by array of glioblastoma-derived neural stem cells
2012-09-21 | E-MTAB-972 | biostudies-arrayexpress
Genomics ATAC-seq of BMP response in glioblastoma-derived neural stem cells
2015-10-01 | E-MTAB-3868 | biostudies-arrayexpress
Transcriptomics High-resolution methylation profiling of glioblastoma neural stem cells and reprogrammed derivatives
2013-03-15 | E-MTAB-1271 | biostudies-arrayexpress
Transcriptomics MicroRNA expression profiling of normal and glioblastoma-derived neural stem cells
2016-11-01 | E-MTAB-3865 | biostudies-arrayexpress
Transcriptomics Expression profiling of glioblastoma neural stem cells and reprogrammed derivatives
2013-03-15 | E-MTAB-1273 | biostudies-arrayexpress
Transcriptomics RNA-seq of BMP response in glioblastoma-derived neural stem cells
2015-10-02 | E-MTAB-3867 | biostudies-arrayexpress
Transcriptomics Expression profiling of normal and glioblastoma-derived neural stem cells
2015-10-01 | E-MTAB-3864 | biostudies-arrayexpress
Transcriptomics DNA methylation profiling of core glioma stem cells: a novel glioblastoma cell population with diminished antigen presentation
2022-05-11 | E-MTAB-10978 | biostudies-arrayexpress