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ATAC-seq of BMP response in glioblastoma-derived neural stem cells

ABSTRACT: Chromatin accessibility was profiled by ATAC-seq in normal and glioblastoma-derived neural stem (GNS) cells, in self-renewing conditions and in response to differentiation stimulus with bone morphogenic protein (BMP).

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Homo sapiens

SUBMITTER: Paul Bertone 

PROVIDER: E-MTAB-3868 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Glioblastoma Stem Cells Respond to Differentiation Cues but Fail to Undergo Commitment and Terminal Cell-Cycle Arrest.

Carén Helena H   Stricker Stefan H SH   Bulstrode Harry H   Gagrica Sladjana S   Johnstone Ewan E   Bartlett Thomas E TE   Feber Andrew A   Wilson Gareth G   Teschendorff Andrew E AE   Bertone Paul P   Beck Stephan S   Pollard Steven M SM  

Stem cell reports 20151101 5

Glioblastoma (GBM) is an aggressive brain tumor whose growth is driven by stemcell-like cells. BMP signaling triggers cell-cycle exit and differentiation of GBM stemcells (GSCs) and, therefore, might have therapeutic value. However, the epigenetic mechanisms that accompany differentiation remain poorly defined. It is also unclear whether cell-cycle arrest is terminal. Herewe find only a subset ofGSCcultures exhibit astrocyte differentiation in response to BMP. Although overtly differentiated non  ...[more]

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