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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of chronic type and acute type adult T-cell leukemia/lymphoma to detect the disease genes

ABSTRACT: Comprehensive gene expression profiles of thirteen samples of chronic type ATL and twenty one samples of acute type ATL were analyzed to detect tumor-specific genes. We studied a total of 34 adult T-cell leuekmia/lymphoma cases, whose samples and clinical data were available.

ORGANISM(S): Homo sapiens

SUBMITTER: Noriaki Yoshida

PROVIDER: E-MTAB-1798 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of FOXO3 and PRDM1 as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analyses.

Karube Kennosuke K Nakagawa Masao M Tsuzuki Shinobu S Takeuchi Ichiro I Honma Keiichiro K Nakashima Yasuhiro Y Shimizu Norio N Ko Young-Hyeh YH Morishima Yasuo Y Ohshima Koichi K Nakamura Shigeo S Seto Masao M

Blood 20110620 12

Oligo-array comparative genomic hybridization (CGH) and gene-expression profiling of natural killer (NK)-cell neoplasms were used in an effort to delineate the molecular pathogenesis involved. Oligo-array CGH identified two 6q21 regions that were most frequently deleted (14 of 39 or 36%). One of these regions included POPDC3, PREP, PRDM1, ATG5, and AIM1, whereas the other included LACE1 and FOXO3. All genes located in these regions, except for POPDC3 and AIM1, were down-regulated in neoplastic s ...[more]

PMID: 21690554

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