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Transcriptional profiling by array of Burkholderia cenocepacia clonal variants IST439 and IST4113

ABSTRACT: In this work the genomic expression of two Burkholderia cenocepacia clonal variants (IST439 and IST4113) were compared. These isolates were collected from a chronically colonized cystic-fibrosis patient that has died from the cepacia syndrome. IST439 was the first B. cenocepacia isolate recovered from the patient and it is thought to have initiated the infection while the IST4113 isolate was recovered three years later, after a period of exacerbated infection that compelled the patient to hospitalization and intravenous therapy with gentamicine and ceftazidime. Among other phenotypic differences, IST4113 is much more resistant to a wide range of antimicrobials tested with very different biological targets

ORGANISM(S): Burkholderia cenocepacia

SUBMITTER: Nuno Mira 

PROVIDER: E-MTAB-809 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genomic expression analysis reveals strategies of Burkholderia cenocepacia to adapt to cystic fibrosis patients' airways and antimicrobial therapy.

Mira Nuno P NP   Madeira Andreia A   Moreira Ana Sílvia AS   Coutinho Carla P CP   Sá-Correia Isabel I  

PloS one 20111221 12

Pulmonary colonization of cystic fibrosis (CF) patients with Burkholderia cenocepacia or other bacteria of the Burkholderia cepacia complex (Bcc) is associated with worse prognosis and increased risk of death. During colonization, the bacteria may evolve under the stressing selection pressures exerted in the CF lung, in particular, those resulting from challenges of the host immune defenses, antimicrobial therapy, nutrient availability and oxygen limitation. Understanding the adaptive mechanisms  ...[more]

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