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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse male embryos treated with DMSO or 17beta-estradiol in wild type or ERalpha knock outs to assess the toxic effects of oestrogen exposure in fetal testis

ABSTRACT: assess the toxicogenomic effets of estrogen exposure in fetal testis

ORGANISM(S): Mus musculus

SUBMITTER: Olivier Schaad

PROVIDER: E-TABM-275 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Estrogen receptor alpha is a major contributor to estrogen-mediated fetal testis dysgenesis and cryptorchidism.

Cederroth Christopher R CR Schaad Olivier O Descombes Patrick P Chambon Pierre P Vassalli Jean-Dominique JD Nef Serge S

Endocrinology 20070802 11

Failure of the testes to descend into the scrotum (cryptorchidism) is one of the most common birth defects in humans. In utero exposure to estrogens, such as 17beta-estradiol (E2) or the synthetic estrogen diethylstilbestrol (DES), down-regulates insulin-like 3 (Insl3) expression in embryonic Leydig cells, which in turn results in cryptorchidism in mice. To identify the molecular mechanism whereby xenoestrogens block Insl3 gene transcription, we performed a microarray analysis of wild-type or es ...[more]

PMID: 17673513

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