Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

61 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcription profiling of chicken whole eye and retinal ganglion cells (RGC) to identify RGC-specific genes

ABSTRACT: Identification of genes regulated by ATH5 in a dose-dependent manner.; Identification of retinal ganglion cells (RGC)-specific genes.

ORGANISM(S): Gallus gallus

SUBMITTER: Jean-Marc Matter

PROVIDER: E-TABM-417 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Publications

Conserved regulatory sequences in Atoh7 mediate non-conserved regulatory responses in retina ontogenesis.

Skowronska-Krawczyk Dorota D Chiodini Florence F Ebeling Martin M Alliod Christine C Kundzewicz Adam A Castro Diogo D Ballivet Marc M Guillemot François F Matter-Sadzinski Lidia L Matter Jean-Marc JM

Development (Cambridge, England) 20091101 22

The characterisation of interspecies differences in gene regulation is crucial to understanding the molecular basis of phenotypic diversity and evolution. The atonal homologue Atoh7 participates in the ontogenesis of the vertebrate retina. Our study reveals how evolutionarily conserved, non-coding DNA sequences mediate both the conserved and the species-specific transcriptional features of the Atoh7 gene. In the mouse and chick retina, species-related variations in the chromatin-binding profiles ...[more]

PMID: 19855019

Similar Datasets

Transcription profiling of mouse primary osteoblastic cells after intermittent of continuous treatment with parathyroid hormone to investigate the role of beta-arrestin2

Project description:Role of beta-arrestin2 in response to intermittent or continuous parathyroid hormone (PTH) treatment.

2009-07-20 | E-TABM-624 | biostudies-arrayexpress

Transcription profiling of human, mouse and rat differentiated cell sub-types leading to sperm formation

Project description:Gene Expression profiling Study of Spermatogenesis. Comparison of the differenciated cells sub-types leading to sperm formation.

2007-05-11 | E-TABM-130 | biostudies-arrayexpress

Transcription profiling of mouse male embryos treated with DMSO or 17beta-estradiol in wild type or ERalpha knock outs to assess the toxic effects of oestrogen exposure in fetal testis

Project description:assess the toxicogenomic effets of estrogen exposure in fetal testis

2007-10-09 | E-TABM-275 | biostudies-arrayexpress

Transcription profiling of skeletal muscle from amyotrophic lateral sclerosis sod1(G86R) axotomized mice and control mice to monitor denervation-dependent gene expression in an Amyotrophic lateral sclerosis (ALS) mouse model

Project description:Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neuromuscular disorder characterized by the selective degeneration of upper and lower motor neurons, progressive muscle wasting and paralysis. To define the full set of alterations in gene expression in skeletal muscle during the course of the disease, we performed high-density oligonucleotide microarray analysis of gene expression in hind limb skeletal muscles of sod1(G86R) mice, one of the existing transgenic models of ALS. To monitor denervation-dependent gene expression, we determined the effects of short-term acute denervation on the muscle transcriptome after sciatic nerve axotomy.

2008-01-05 | E-TABM-195 | biostudies-arrayexpress

Transcription profiling of human testis samples from men with highly defined and homogenous testicular pathologies reveals patterns that correlate with distinct stages of spermatogenesis

Project description:Identification of gene expression patterns that correlate with distinct stages of male germ cell development using biopsies from men with highly defined and homogenous testicular pathologies based on the Johnsen score procedure. The Johnsen score procedure is a classical histopathological scoring procedure that classifies the germ cell composition from different stages of spermatogenic impairment.

2008-06-11 | E-TABM-234 | biostudies-arrayexpress

Transcription profiling of mice mutant for Sox8 and Sox9 has early testicular sterility

Project description:To study a possible redundant role of mouse Sox8 and Sox9 after testis induction we generated double mutants by AMH-Cre conditional inactivation of Sox9 in a Sox8-/- background. Double mutants arrest spermatogenesis in early pubescence. We performed expression profiling to explore causes. AMH-Cre/+;Sox9flox/flox;Sox8-/- is a conditional homozygous knockout of SOX9 in a sox8-/- background, using an AMH-CRE line where the CRE recombinase is expressed under the promoter region of the human AMH gene in Sertoli cells starting at E13.5. The specific cross was between males of the genotype +/+;Sox9flox/flox;Sox8-/- and females of the genotype AMH-Cre/+;Sox9flox/flox;Sox8+/-.

2013-01-03 | E-TABM-531 | biostudies-arrayexpress

Transcription profiling of testis from wild type mice and mice with a Sertoli-specific ablation of Dicer

Project description:Assess the transcriptomic effects of Sertoli-specific ablation of Dicer in mice

2009-01-06 | E-TABM-426 | biostudies-arrayexpress

Transcription profiling of liver from wild type, Rev knock out and Rev-erb-alpha transcgenic mice to identify target genes of PAR bZip

Project description:Found PAR bZip target genes. The loss of circadian PAR bZip transcription factors results in epilepsy, DBP (albumin D-site-binding protein), HLF (hepatic leukemia factor), and TEF (thyrotroph embryonic factor) are the three members of the PAR bZip (proline and acidic amino acid-rich basic leucine zipper) transcription factor family. All three of these transcriptional regulatory proteins accumulate with robust circadian rhythms in tissues with high amplitudes of clock gene expression, such as the suprachiasmatic nucleus (SCN) and the liver. However, they are expressed at nearly invariable levels in most brain regions, in which clock gene expression only cycles with low amplitude. Here we show that mice deficient for all three PAR bZip proteins are highly susceptible to generalized spontaneous and audiogenic epilepsies that frequently are lethal. Transcriptome profiling revealed pyridoxal kinase (Pdxk) as a target gene of PAR bZip proteins in both liver and brain. Pyridoxal kinase converts vitamin B6 derivatives into pyridoxal phosphate (PLP), the coenzyme of many enzymes involved in amino acid and neurotransmitter metabolism. PAR bZip-deficient mice show decreased brain levels of PLP, serotonin, and dopamine, and such changes have previously been reported to cause epilepsies in other systems. Hence, the expression of some clock-controlled genes, such as Pdxk, may have to remain within narrow limits in the brain. This could explain why the circadian oscillator has evolved to generate only low-amplitude cycles in most brain regions.; find REV-ERB ALPHA target genes

2010-06-22 | E-TABM-726 | biostudies-arrayexpress

John Cobb 2006

Project description:The goal of the experiment was to identify genes downstream of the SHOX2 transcription factor during mouse forelimb development. Triplicate Samples were isolated from Shox2 mutants and wildtype/heterozygote limbs at E10.5 and E11.5.

2011-09-23 | E-MTAB-411 | biostudies-arrayexpress

Transcription profiling of mouse liver after miR-122 inactivation at two Zeitgeber time points, ZT0 and ZT12

Project description:Detection of transcriptome changes associated with miR-122 inactivation in mouse liver at two Zeitgeber time points, ZT0 and ZT12.

2009-06-03 | E-TABM-692 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data