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Transcription profiling of chicken whole eye and retinal ganglion cells (RGC) to identify RGC-specific genes

ABSTRACT: Identification of genes regulated by ATH5 in a dose-dependent manner.; Identification of retinal ganglion cells (RGC)-specific genes.

ORGANISM(S): Gallus gallus

SUBMITTER: Jean-Marc Matter

PROVIDER: E-TABM-417 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Conserved regulatory sequences in Atoh7 mediate non-conserved regulatory responses in retina ontogenesis.

Skowronska-Krawczyk Dorota D Chiodini Florence F Ebeling Martin M Alliod Christine C Kundzewicz Adam A Castro Diogo D Ballivet Marc M Guillemot François F Matter-Sadzinski Lidia L Matter Jean-Marc JM

Development (Cambridge, England) 20091101 22

The characterisation of interspecies differences in gene regulation is crucial to understanding the molecular basis of phenotypic diversity and evolution. The atonal homologue Atoh7 participates in the ontogenesis of the vertebrate retina. Our study reveals how evolutionarily conserved, non-coding DNA sequences mediate both the conserved and the species-specific transcriptional features of the Atoh7 gene. In the mouse and chick retina, species-related variations in the chromatin-binding profiles ...[more]

PMID: 19855019

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