Ontology highlight
ABSTRACT:
SUBMITTER: Wardrop DJ
PROVIDER: S-EPMC2812663 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20100201 4
The development of a versatile method for the preparation of five- to eight-membered hydroxy lactams that involves the iodine(III)-mediated oxamidation of unsaturated O-alkyl hydroxamates is described. This transformation, which is believed to proceed through the intermediacy of singlet nitrenium and bicyclic N-acyl-N-alkoxyaziridinium ions, is both stereospecific and highly regioselective in most of the 22 cases examined. ...[more]