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A mild and efficient approach to enantioenriched ?-hydroxyethyl ?,?-unsaturated ?-lactams.
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ABSTRACT:
SUBMITTER: Han SJ
PROVIDER: S-EPMC4864989 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
A mild and efficient approach to enantioenriched α-hydroxyethyl α,β-unsaturated δ-lactams.
Tetrahedron letters 20160501 21
A straightforward approach toward enantioenriched α-substituted α,β-unsaturated δ-lactams is described. Although a considerable number of approches toward α,β-unsaturated δ-lactams have been reported, there are relatively few examples of enantioenriched α,δ-disubstituted α,β-unsaturated δ-lactams formation. The δ-stereocenter was formed by addition of allylmagnesium bromide to an <i>N</i>-<i>tert</i>-butylsulfinyl imine. The α,β-unsaturated δ-lactam was furnished by ring-closing metathesis. Alth ...[more]