Ontology highlight
ABSTRACT:
SUBMITTER: Ippagunta SK
PROVIDER: S-EPMC3178750 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Ippagunta Sirish K SK Malireddi R K Subbarao RK Shaw Patrick J PJ Neale Geoffrey A GA Vande Walle Lieselotte L Green Douglas R DR Fukui Yoshinori Y Lamkanfi Mohamed M Kanneganti Thirumala-Devi TD
Nature immunology 20110904 10
The adaptor ASC contributes to innate immunity through the assembly of inflammasome complexes that activate the cysteine protease caspase-1. Here we demonstrate that ASC has an inflammasome-independent, cell-intrinsic role in cells of the adaptive immune response. ASC-deficient mice showed defective antigen presentation by dendritic cells (DCs) and lymphocyte migration due to impaired actin polymerization mediated by the small GTPase Rac. Genome-wide analysis showed that ASC, but not the cytopla ...[more]