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Pd(II)-catalyzed enantioselective C-H activation of cyclopropanes.

ABSTRACT: Systematic ligand development has led to the identification of novel mono-N-protected amino acid ligands for Pd(II)-catalyzed enantioselective C-H activation of cyclopropanes. A diverse range of organoboron reagents can be used as coupling partners, and the reaction proceeds under mild conditions. These results provide a new retrosynthetic disconnection for the construction of enantioenriched cis-substituted cyclopropanecarboxylic acids.

SUBMITTER: Wasa M

PROVIDER: S-EPMC3241475 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature

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Pd(II)-catalyzed enantioselective C-H activation of cyclopropanes.

Wasa Masayuki M Engle Keary M KM Lin David W DW Yoo Eun Jeong EJ Yu Jin-Quan JQ

Journal of the American Chemical Society 20111121 49

Systematic ligand development has led to the identification of novel mono-N-protected amino acid ligands for Pd(II)-catalyzed enantioselective C-H activation of cyclopropanes. A diverse range of organoboron reagents can be used as coupling partners, and the reaction proceeds under mild conditions. These results provide a new retrosynthetic disconnection for the construction of enantioenriched cis-substituted cyclopropanecarboxylic acids. ...[more]

PMID: 22059375

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