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Bis(?-trimethyl-silanolato-?O:O)bis-{[2-(2H-benzotriazol-2-yl)-4,6-di-tert-pentyl-phenolato-?N,O]zinc}.

ABSTRACT: The binuclear title complex, [Zn(2)(C(22)H(28)N(3)O)(2)(C(3)H(9)OSi)(2)], has a crystallographic imposed centre of symmetry. The Zn(II) atom is coordinated by three O and one N atom from one 2-(2H-benzotriazol-2-yl)-4,6-di-tert-pentyl-phenolate ligand and two bridging trimethyl-silanolate anions in a distorted tetra-hedral geometry. The dihedral angle between the benzotriazole ring system and the benzene ring is 19.83?(5)°. The tert-pentyl groups are disordered over two orientations with refined site-occupancy ratios of 0.858?(4):0.142?(4) and 0.665?(6):0.335?(6).

SUBMITTER: Lee HH

PROVIDER: S-EPMC3254346 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature

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Bis(μ-trimethyl-silanolato-κO:O)bis-{[2-(2H-benzotriazol-2-yl)-4,6-di-tert-pentyl-phenolato-κN,O]zinc}.

Lee Hwi Hyun HH Go Min Jeong MJ Park Ka Hyun KH Kim Youngjo Y Lee Junseong J

Acta crystallographica. Section E, Structure reports online 20111223 Pt 1

The binuclear title complex, [Zn(2)(C(22)H(28)N(3)O)(2)(C(3)H(9)OSi)(2)], has a crystallographic imposed centre of symmetry. The Zn(II) atom is coordinated by three O and one N atom from one 2-(2H-benzotriazol-2-yl)-4,6-di-tert-pentyl-phenolate ligand and two bridging trimethyl-silanolate anions in a distorted tetra-hedral geometry. The dihedral angle between the benzotriazole ring system and the benzene ring is 19.83 (5)°. The tert-pentyl groups are disordered over two orientations with refined ...[more]

PMID: 22259380

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Project description:2-(2H-Benzotriazol-2-yl)-4,6-di-tert-pentylphenol (UV 328; CAS: 25973-55-1) is an ultraviolet light (UV) absorber which belongs to the class of hydroxy phenol benzotriazoles. Therefore, UV 328 is added to plastics and other polymers due to its photostability to prevent discoloration and prolong product stability which may result in an exposure of consumers. However, information about the toxic effects on humans and the human metabolism are still lacking. In the present study, human metabolism pathways of UV 328 and its elimination kinetics were explored. For that purpose, three healthy volunteers were orally exposed to a single dose of 0.3 mg UV 328/kg bodyweight. UV 328 and its metabolites were investigated in blood and urine samples collected until 48 and 72 h after exposure, respectively. Thereby, previously published analytical procedures were applied for the sample analysis using dispersive liquid-liquid microextraction and subsequent measurement via gas chromatography coupled to tandem mass spectrometry with advanced electron ionization. UV 328 was found to be oxidized at its alkyl side chains leading to the formation of hydroxy and/or oxo function with maximum blood concentrations at 8-10 h after exposure for UV 328-6/3-OH, UV 328-4/3-OH and UV 328-4/3-CO. In contrast, a plateau for UV 328-4/3-CO-6/3-OH levels was reached around 10 h post-dosage. The highest blood levels were found for native UV 328 at 8 h after ingestion. Furthermore, biphasic elimination kinetics in blood were revealed for almost all detected metabolites. UV 328 and its metabolites did not occur in blood as conjugates. The renal elimination kinetics were very similar with the kinetics in blood. However, the prominence of the metabolites in urine was somewhat different compared to blood. In contrast, mostly conjugated metabolites occurred for renal elimination. In urine, UV 328-4/3-CO-6/3-OH was found to be the most dominant urinary biomarker followed by UV 328-6/3-OH and UV 328-4/3-OH. In total, approximately 0.1% of the orally administered dose was recovered in urine within 72 h. Although high levels of UV 328 in blood proved good resorption and high systemic availability of the substance in the human body, the urine results revealed a rather low quantitative metabolism and urinary excretion rate. Consequently, biliary excretion as part of the enterohepatic cycle and elimination via feces are assumed to be the preferred pathways instead of renal elimination.

Dataset Information

Bis(?-trimethyl-silanolato-?O:O)bis-{[2-(2H-benzotriazol-2-yl)-4,6-di-tert-pentyl-phenolato-?N,O]zinc}.

Publications

Bis(μ-trimethyl-silanolato-κO:O)bis-{[2-(2H-benzotriazol-2-yl)-4,6-di-tert-pentyl-phenolato-κN,O]zinc}.

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