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New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri.

ABSTRACT: Six new cembranoids, cherbonolides A-E (1?5) and bischerbolide peroxide (6), along with one known cembranoid, isosarcophine (7), were isolated from the Formosan soft coral Sarcophyton cherbonnieri. The structures of these compounds were elucidated by detailed spectroscopic analysis and chemical methods. Compound 6 was discovered to be the first example of a molecular skeleton formed from two cembranoids connected by a peroxide group. Compounds 1?7 were shown to have the ability of inhibiting the production of superoxide anions and elastase release in N-formyl-methionyl-leucyl-phenyl-alanine/cytochalasin B (fMLF/CB)-induced human neutrophils.

SUBMITTER: Peng CC

PROVIDER: S-EPMC6117711 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri.

Peng Chia-Chi CC Huang Chiung-Yao CY Ahmed Atallah F AF Hwang Tsong-Long TL Dai Chang-Feng CF Sheu Jyh-Horng JH

Marine drugs 20180806 8

Six new cembranoids, cherbonolides A-E (1⁻5) and bischerbolide peroxide (6), along with one known cembranoid, isosarcophine (7), were isolated from the Formosan soft coral Sarcophyton cherbonnieri. The structures of these compounds were elucidated by detailed spectroscopic analysis and chemical methods. Compound 6 was discovered to be the first example of a molecular skeleton formed from two cembranoids connected by a peroxide group. Compounds 1⁻< ...[more]

PMID: 30082637

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