Ontology highlight
ABSTRACT:
SUBMITTER: Mukthavaram R
PROVIDER: S-EPMC3808212 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Mukthavaram Rajesh R Jiang Pengfei P Saklecha Rohit R Simberg Dmitri D Bharati Ila Sri IS Nomura Natsuko N Chao Ying Y Pastorino Sandra S Pingle Sandeep C SC Fogal Valentina V Wrasidlo Wolf W Makale Milan M Kesari Santosh S
International journal of nanomedicine 20131021
Staurosporine (STS) is a potent pan-kinase inhibitor with marked activity against several chemotherapy-resistant tumor types in vitro. The translational progress of this compound has been hindered by poor pharmacokinetics and toxicity. We sought to determine whether liposomal encapsulation of STS would enhance antitumor efficacy and reduce toxicity, thereby supporting the feasibility of further preclinical development. We developed a novel reverse pH gradient liposomal loading method for STS, wi ...[more]