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Boc groups as protectors and directors for Ir-catalyzed C-H borylation of heterocycles.

ABSTRACT: Ir-catalyzed C-H borylation is found to be compatible with Boc protecting groups. Thus, pyrroles, indoles, and azaindoles can be selectively functionalized at C-H positions beta to N. The Boc group can be removed on thermolysis or left intact during subsequent transformations.

SUBMITTER: Kallepalli VA

PROVIDER: S-EPMC3876461 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature

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Boc groups as protectors and directors for Ir-catalyzed C-H borylation of heterocycles.

Kallepalli Venkata A VA Shi Feng F Paul Sulagna S Onyeozili Edith N EN Maleczka Robert E RE Smith Milton R MR

The Journal of organic chemistry 20091201 23

Ir-catalyzed C-H borylation is found to be compatible with Boc protecting groups. Thus, pyrroles, indoles, and azaindoles can be selectively functionalized at C-H positions beta to N. The Boc group can be removed on thermolysis or left intact during subsequent transformations. ...[more]

PMID: 19894699

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