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Chlorotrifluoroethylidenes: an efficient and convenient approach to their synthesis.

ABSTRACT: A convenient one step synthesis of chlorotrifluoroalkyl olefins starting from aldehydes was developed. The stable reagent 2-((1-chloro-2,2,2-trifluoroethyl)sulfonyl)benzothiazole was prepared from readily available benzothiazole-2-thiol and halothane. This method comprises using stable 2-((1-chloro-2,2,2-trifluoroethyl)sulfonyl)benzothiazole according to the Julia procedure and presents new opportunities for the synthesis of trifluoroalkylidene derivatives.

SUBMITTER: Upare AA

PROVIDER: S-EPMC9053503 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Chlorotrifluoroethylidenes: an efficient and convenient approach to their synthesis.

Upare Abhay Atmaram AA Gadekar Pradip K PK Jadhav Kiran K Sivaramakrishnan H H Roopan Selvaraj Mohana SM

RSC advances 20200505 30

A convenient one step synthesis of chlorotrifluoroalkyl olefins starting from aldehydes was developed. The stable reagent 2-((1-chloro-2,2,2-trifluoroethyl)sulfonyl)benzothiazole was prepared from readily available benzothiazole-2-thiol and halothane. This method comprises using stable 2-((1-chloro-2,2,2-trifluoroethyl)sulfonyl)benzothiazole according to the Julia procedure and presents new opportunities for the synthesis of trifluoroalkylidene derivatives. ...[more]

PMID: 35515602

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