Dataset Information
CryoEM structure of hM4Di-miniGo in complex with DCZ
Ontology highlight
ABSTRACT:
SUBMITTER: Jonathan Firoze Fay
PROVIDER: EMPIAR-11184 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Molecular basis for selective activation of DREADD-based chemogenetics.
Nature 20221130 7939
Designer receptors exclusively activated by designer drugs (DREADDs) represent a powerful chemogenetic technology for the remote control of neuronal activity and cellular signalling<sup>1-4</sup>. The muscarinic receptor-based DREADDs are the most widely used chemogenetic tools in neuroscience research. The G<sub>q</sub>-coupled DREADD (hM3Dq) is used to enhance neuronal activity, whereas the G<sub>i/o</sub>-coupled DREADD (hM4Di) is utilized to inhibit neuronal activity<sup>5</sup>. Here we rep ...[more]
