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Cryo-electron tomography data acquired on S. cerevisiae (BY4741) cryo-FIB lamellae

ABSTRACT:

SUBMITTER: Marie-Christin Spindler

PROVIDER: EMPIAR-12104 | biostudies-other |

REPOSITORIES: biostudies-other

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Publications

Polysome collapse and RNA condensation fluidize the cytoplasm.

Xie Ying Y Shu Tong T Liu Tiewei T Spindler Marie-Christin MC Mahamid Julia J Hocky Glen M GM Gresham David D Holt Liam J LJ

Molecular cell 20240701 14

The cell interior is packed with macromolecules of mesoscale size, and this crowded milieu significantly influences cellular physiology. Cellular stress responses almost universally lead to inhibition of translation, resulting in polysome collapse and release of mRNA. The released mRNA molecules condense with RNA-binding proteins to form ribonucleoprotein (RNP) condensates known as processing bodies and stress granules. Here, we show that polysome collapse and condensation of RNA transiently flu ...[more]

PMID: 39059370

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