Ontology highlight
ABSTRACT:
SUBMITTER: Darwish A
PROVIDER: S-EPMC4025841 | biostudies-other | 2012 Apr
REPOSITORIES: biostudies-other
Darwish Alla A Blacker Megan M Janzen Nancy N Rathmann Stephanie M SM Czorny Shannon S Hillier Shawn M SM Joyal John L JL Babich John W JW Valliant John F JF
ACS medicinal chemistry letters 20120218 4
A new prosthetic group referred to as the triazole appending agent (TAAG) was developed as a means to prepare targeted radioiodine-based molecular imaging and therapy agents. Tributyltin-TAAG and the fluorous analogue were synthesized in high yield using simple click chemistry and the products labeled in greater than 95% RCY with (123)I. A TAAG derivative of an inhibitor of prostate-specific membrane antigen was prepared and radiolabeled with (123)I in 85% yield where biodistribution studies in ...[more]